Cargando…

Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region

Background: This review aimed to identify hepatitis C virus (HCV) prevalence estimates among the general population and six key populations (people who inject drugs, men who have sex with men, sex workers, prisoners/detainees, Indigenous people, and migrants) in the World Health Organization Western...

Descripción completa

Detalles Bibliográficos
Autores principales: Iversen, Jenny, Wand, Handan, Chan, Po-Lin, Le, Linh-Vi, Maher, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320901/
https://www.ncbi.nlm.nih.gov/pubmed/35891529
http://dx.doi.org/10.3390/v14071548
_version_ 1784755906423029760
author Iversen, Jenny
Wand, Handan
Chan, Po-Lin
Le, Linh-Vi
Maher, Lisa
author_facet Iversen, Jenny
Wand, Handan
Chan, Po-Lin
Le, Linh-Vi
Maher, Lisa
author_sort Iversen, Jenny
collection PubMed
description Background: This review aimed to identify hepatitis C virus (HCV) prevalence estimates among the general population and six key populations (people who inject drugs, men who have sex with men, sex workers, prisoners/detainees, Indigenous people, and migrants) in the World Health Organization Western Pacific Region (WHO WPR). Methods: Original research articles published between 2016 and 2020 were identified from bibliographic databases. Publications were retrieved, replicas removed, and abstracts screened. Retained full texts were assessed and excluded if inclusion criteria were not met. Methodological quality was assessed using the Johanna Briggs Institute critical appraisal checklist for prevalence data. Data on HCV exposure and active infection were extracted and aggregated and forest plots generated for each population by country. Results: There were no HCV prevalence estimates in any population for more than half of WPR countries and territories. Among the 76 estimates, 97% presented prevalence of exposure and 33% prevalence of active infection. General population viraemic prevalence was 1% or less, except in Mongolia. Results confirm the endemic nature of HCV among people who inject drugs, with estimates of exposure ranging from 30% in Cambodia to 76% in Hong Kong. Conclusions: Countries require detailed knowledge of HCV prevalence in diverse populations to evaluate the impact of efforts to support WHO HCV elimination goals. Results provide baseline estimates from which to monitor and evaluate progress and by which to benchmark future elimination efforts.
format Online
Article
Text
id pubmed-9320901
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93209012022-07-27 Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region Iversen, Jenny Wand, Handan Chan, Po-Lin Le, Linh-Vi Maher, Lisa Viruses Review Background: This review aimed to identify hepatitis C virus (HCV) prevalence estimates among the general population and six key populations (people who inject drugs, men who have sex with men, sex workers, prisoners/detainees, Indigenous people, and migrants) in the World Health Organization Western Pacific Region (WHO WPR). Methods: Original research articles published between 2016 and 2020 were identified from bibliographic databases. Publications were retrieved, replicas removed, and abstracts screened. Retained full texts were assessed and excluded if inclusion criteria were not met. Methodological quality was assessed using the Johanna Briggs Institute critical appraisal checklist for prevalence data. Data on HCV exposure and active infection were extracted and aggregated and forest plots generated for each population by country. Results: There were no HCV prevalence estimates in any population for more than half of WPR countries and territories. Among the 76 estimates, 97% presented prevalence of exposure and 33% prevalence of active infection. General population viraemic prevalence was 1% or less, except in Mongolia. Results confirm the endemic nature of HCV among people who inject drugs, with estimates of exposure ranging from 30% in Cambodia to 76% in Hong Kong. Conclusions: Countries require detailed knowledge of HCV prevalence in diverse populations to evaluate the impact of efforts to support WHO HCV elimination goals. Results provide baseline estimates from which to monitor and evaluate progress and by which to benchmark future elimination efforts. MDPI 2022-07-15 /pmc/articles/PMC9320901/ /pubmed/35891529 http://dx.doi.org/10.3390/v14071548 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Iversen, Jenny
Wand, Handan
Chan, Po-Lin
Le, Linh-Vi
Maher, Lisa
Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title_full Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title_fullStr Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title_full_unstemmed Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title_short Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region
title_sort systematic review of hepatitis c virus prevalence in the who western pacific region
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320901/
https://www.ncbi.nlm.nih.gov/pubmed/35891529
http://dx.doi.org/10.3390/v14071548
work_keys_str_mv AT iversenjenny systematicreviewofhepatitiscvirusprevalenceinthewhowesternpacificregion
AT wandhandan systematicreviewofhepatitiscvirusprevalenceinthewhowesternpacificregion
AT chanpolin systematicreviewofhepatitiscvirusprevalenceinthewhowesternpacificregion
AT lelinhvi systematicreviewofhepatitiscvirusprevalenceinthewhowesternpacificregion
AT maherlisa systematicreviewofhepatitiscvirusprevalenceinthewhowesternpacificregion