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Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy

Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Qu, Yanfei, Zhang, Ziyi, Huang, Hao, Xu, Yufei, Shen, Fengyun, Wang, Lihua, Sun, Lele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320917/
https://www.ncbi.nlm.nih.gov/pubmed/35877485
http://dx.doi.org/10.3390/gels8070400
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author Wang, Qi
Qu, Yanfei
Zhang, Ziyi
Huang, Hao
Xu, Yufei
Shen, Fengyun
Wang, Lihua
Sun, Lele
author_facet Wang, Qi
Qu, Yanfei
Zhang, Ziyi
Huang, Hao
Xu, Yufei
Shen, Fengyun
Wang, Lihua
Sun, Lele
author_sort Wang, Qi
collection PubMed
description Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions.
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spelling pubmed-93209172022-07-27 Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy Wang, Qi Qu, Yanfei Zhang, Ziyi Huang, Hao Xu, Yufei Shen, Fengyun Wang, Lihua Sun, Lele Gels Review Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions. MDPI 2022-06-24 /pmc/articles/PMC9320917/ /pubmed/35877485 http://dx.doi.org/10.3390/gels8070400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Qi
Qu, Yanfei
Zhang, Ziyi
Huang, Hao
Xu, Yufei
Shen, Fengyun
Wang, Lihua
Sun, Lele
Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title_full Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title_fullStr Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title_full_unstemmed Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title_short Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
title_sort injectable dna hydrogel-based local drug delivery and immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320917/
https://www.ncbi.nlm.nih.gov/pubmed/35877485
http://dx.doi.org/10.3390/gels8070400
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