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Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy
Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320917/ https://www.ncbi.nlm.nih.gov/pubmed/35877485 http://dx.doi.org/10.3390/gels8070400 |
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author | Wang, Qi Qu, Yanfei Zhang, Ziyi Huang, Hao Xu, Yufei Shen, Fengyun Wang, Lihua Sun, Lele |
author_facet | Wang, Qi Qu, Yanfei Zhang, Ziyi Huang, Hao Xu, Yufei Shen, Fengyun Wang, Lihua Sun, Lele |
author_sort | Wang, Qi |
collection | PubMed |
description | Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions. |
format | Online Article Text |
id | pubmed-9320917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93209172022-07-27 Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy Wang, Qi Qu, Yanfei Zhang, Ziyi Huang, Hao Xu, Yufei Shen, Fengyun Wang, Lihua Sun, Lele Gels Review Regulated drug delivery is an important direction in the field of medicine and healthcare research. In recent years, injectable hydrogels with good biocompatibility and biodegradability have attracted extensive attention due to their promising application in controlled drug release. Among them, DNA hydrogel has shown great potentials in local drug delivery and immunotherapy. DNA hydrogel is a three-dimensional network formed by cross-linking of hydrophilic DNA strands with extremely good biocompatibility. Benefiting from the special properties of DNA, including editable sequence and specificity of hybridization reactions, the mechanical properties and functions of DNA hydrogels can be precisely designed according to specific applications. In addition, other functional materials, including peptides, proteins and synthetic organic polymers can be easily integrated with DNA hydrogels, thereby enriching the functions of the hydrogels. In this review, we first summarize the types and synthesis methods of DNA hydrogels, and then review the recent research progress of injectable DNA hydrogels in local drug delivery, especially in immunotherapy. Finally, we discuss the challenges facing DNA hydrogels and future development directions. MDPI 2022-06-24 /pmc/articles/PMC9320917/ /pubmed/35877485 http://dx.doi.org/10.3390/gels8070400 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Qi Qu, Yanfei Zhang, Ziyi Huang, Hao Xu, Yufei Shen, Fengyun Wang, Lihua Sun, Lele Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title | Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title_full | Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title_fullStr | Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title_full_unstemmed | Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title_short | Injectable DNA Hydrogel-Based Local Drug Delivery and Immunotherapy |
title_sort | injectable dna hydrogel-based local drug delivery and immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320917/ https://www.ncbi.nlm.nih.gov/pubmed/35877485 http://dx.doi.org/10.3390/gels8070400 |
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