Cargando…

Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension

Endothelial dysfunction represents one of the key pathomechanisms in many diseases, including hypertension. Peripheral arterial tonometry (PAT) evaluates the functional status of microvascular endothelium and offers a biomarker of early, potentially reversible, vascular damage. This study aimed to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Jurko, Tomas, Mestanik, Michal, Mestanikova, Andrea, Zeleňák, Kamil, Jurko, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321176/
https://www.ncbi.nlm.nih.gov/pubmed/35888136
http://dx.doi.org/10.3390/life12071048
_version_ 1784755974288965632
author Jurko, Tomas
Mestanik, Michal
Mestanikova, Andrea
Zeleňák, Kamil
Jurko, Alexander
author_facet Jurko, Tomas
Mestanik, Michal
Mestanikova, Andrea
Zeleňák, Kamil
Jurko, Alexander
author_sort Jurko, Tomas
collection PubMed
description Endothelial dysfunction represents one of the key pathomechanisms in many diseases, including hypertension. Peripheral arterial tonometry (PAT) evaluates the functional status of microvascular endothelium and offers a biomarker of early, potentially reversible, vascular damage. This study aimed to assess endothelial function using conventional and novel indices of PAT in pediatric hypertensives. As such, 100 adolescents with normal blood pressure, and essential and white-coat hypertension were examined using EndoPAT 2000. Conventional reactive hyperemia index (RHI) and novel indices of hyperemic response, including the area under the curve of hyperemic response (AUC), were evaluated. AUC was the only parameter sensitive to the effect of hypertension, with significantly lower values in essential hypertensives compared to normotensives and white-coat hypertensives (p = 0.024, p = 0.032, respectively). AUC was the only parameter significantly correlating with mean ambulatory monitored blood pressure (r = −0.231, p = 0.021). AUC showed a significant negative association with age (p = 0.039), but a significant positive association with pubertal status indexed by plasma levels of dehydroepiandrosterone (p = 0.027). This is the first study reporting early signs of microvascular endothelial dysfunction evaluated using PAT in adolescents with newly diagnosed essential hypertension. Detailed analysis of hyperemic response using overall magnitude indexed by AUC provided a more robust method compared to the conventional evaluation of RHI.
format Online
Article
Text
id pubmed-9321176
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93211762022-07-27 Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension Jurko, Tomas Mestanik, Michal Mestanikova, Andrea Zeleňák, Kamil Jurko, Alexander Life (Basel) Article Endothelial dysfunction represents one of the key pathomechanisms in many diseases, including hypertension. Peripheral arterial tonometry (PAT) evaluates the functional status of microvascular endothelium and offers a biomarker of early, potentially reversible, vascular damage. This study aimed to assess endothelial function using conventional and novel indices of PAT in pediatric hypertensives. As such, 100 adolescents with normal blood pressure, and essential and white-coat hypertension were examined using EndoPAT 2000. Conventional reactive hyperemia index (RHI) and novel indices of hyperemic response, including the area under the curve of hyperemic response (AUC), were evaluated. AUC was the only parameter sensitive to the effect of hypertension, with significantly lower values in essential hypertensives compared to normotensives and white-coat hypertensives (p = 0.024, p = 0.032, respectively). AUC was the only parameter significantly correlating with mean ambulatory monitored blood pressure (r = −0.231, p = 0.021). AUC showed a significant negative association with age (p = 0.039), but a significant positive association with pubertal status indexed by plasma levels of dehydroepiandrosterone (p = 0.027). This is the first study reporting early signs of microvascular endothelial dysfunction evaluated using PAT in adolescents with newly diagnosed essential hypertension. Detailed analysis of hyperemic response using overall magnitude indexed by AUC provided a more robust method compared to the conventional evaluation of RHI. MDPI 2022-07-13 /pmc/articles/PMC9321176/ /pubmed/35888136 http://dx.doi.org/10.3390/life12071048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jurko, Tomas
Mestanik, Michal
Mestanikova, Andrea
Zeleňák, Kamil
Jurko, Alexander
Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title_full Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title_fullStr Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title_full_unstemmed Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title_short Early Signs of Microvascular Endothelial Dysfunction in Adolescents with Newly Diagnosed Essential Hypertension
title_sort early signs of microvascular endothelial dysfunction in adolescents with newly diagnosed essential hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321176/
https://www.ncbi.nlm.nih.gov/pubmed/35888136
http://dx.doi.org/10.3390/life12071048
work_keys_str_mv AT jurkotomas earlysignsofmicrovascularendothelialdysfunctioninadolescentswithnewlydiagnosedessentialhypertension
AT mestanikmichal earlysignsofmicrovascularendothelialdysfunctioninadolescentswithnewlydiagnosedessentialhypertension
AT mestanikovaandrea earlysignsofmicrovascularendothelialdysfunctioninadolescentswithnewlydiagnosedessentialhypertension
AT zelenakkamil earlysignsofmicrovascularendothelialdysfunctioninadolescentswithnewlydiagnosedessentialhypertension
AT jurkoalexander earlysignsofmicrovascularendothelialdysfunctioninadolescentswithnewlydiagnosedessentialhypertension