New Glycosylated Secondary Metabolites from Marine-Derived Bacteria

Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae...

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Detalles Bibliográficos
Autores principales: Anh, Cao Van, Kang, Jong Soon, Lee, Hwa-Sun, Trinh, Phan Thi Hoai, Heo, Chang-Su, Shin, Hee Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321207/
https://www.ncbi.nlm.nih.gov/pubmed/35877757
http://dx.doi.org/10.3390/md20070464
Descripción
Sumario:Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1–3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1–3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI(50) values ranging from 8.0 to 10.9 µM.

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