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New Glycosylated Secondary Metabolites from Marine-Derived Bacteria
Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321207/ https://www.ncbi.nlm.nih.gov/pubmed/35877757 http://dx.doi.org/10.3390/md20070464 |
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author | Anh, Cao Van Kang, Jong Soon Lee, Hwa-Sun Trinh, Phan Thi Hoai Heo, Chang-Su Shin, Hee Jae |
author_facet | Anh, Cao Van Kang, Jong Soon Lee, Hwa-Sun Trinh, Phan Thi Hoai Heo, Chang-Su Shin, Hee Jae |
author_sort | Anh, Cao Van |
collection | PubMed |
description | Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1–3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1–3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI(50) values ranging from 8.0 to 10.9 µM. |
format | Online Article Text |
id | pubmed-9321207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93212072022-07-27 New Glycosylated Secondary Metabolites from Marine-Derived Bacteria Anh, Cao Van Kang, Jong Soon Lee, Hwa-Sun Trinh, Phan Thi Hoai Heo, Chang-Su Shin, Hee Jae Mar Drugs Article Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (1), and two new trehalose lipids (2 and 3), together with three known compounds (4–6) were isolated from two marine-derived bacterial strains, Bacillus siamensis 168CLC-66.1 and Tsukamurella pseudospumae IV19-045. The structures of 1–3 were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of 1–3 against six cancer cell lines was evaluated by SRB assay, and 1 showed moderate activity against all the tested cell lines with GI(50) values ranging from 8.0 to 10.9 µM. MDPI 2022-07-20 /pmc/articles/PMC9321207/ /pubmed/35877757 http://dx.doi.org/10.3390/md20070464 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Anh, Cao Van Kang, Jong Soon Lee, Hwa-Sun Trinh, Phan Thi Hoai Heo, Chang-Su Shin, Hee Jae New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title | New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title_full | New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title_fullStr | New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title_full_unstemmed | New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title_short | New Glycosylated Secondary Metabolites from Marine-Derived Bacteria |
title_sort | new glycosylated secondary metabolites from marine-derived bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321207/ https://www.ncbi.nlm.nih.gov/pubmed/35877757 http://dx.doi.org/10.3390/md20070464 |
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