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New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review
Parkinson’s disease (PD) is a progressive neurodegenerative disease, whose main neuropathological finding is pars compacta degeneration due to the accumulation of Lewy bodies and Lewy neurites, and subsequent dopamine depletion. This leads to an increase in the activity of the subthalamic nucleus (S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321220/ https://www.ncbi.nlm.nih.gov/pubmed/35886651 http://dx.doi.org/10.3390/ijerph19148799 |
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author | Montemurro, Nicola Aliaga, Nelida Graff, Pablo Escribano, Amanda Lizana, Jafeth |
author_facet | Montemurro, Nicola Aliaga, Nelida Graff, Pablo Escribano, Amanda Lizana, Jafeth |
author_sort | Montemurro, Nicola |
collection | PubMed |
description | Parkinson’s disease (PD) is a progressive neurodegenerative disease, whose main neuropathological finding is pars compacta degeneration due to the accumulation of Lewy bodies and Lewy neurites, and subsequent dopamine depletion. This leads to an increase in the activity of the subthalamic nucleus (STN) and the internal globus pallidus (GPi). Understanding functional anatomy is the key to understanding and developing new targets and new technologies that could potentially improve motor and non-motor symptoms in PD. Currently, the classical targets are insufficient to improve the entire wide spectrum of symptoms in PD (especially non-dopaminergic ones) and none are free of the side effects which are not only associated with the procedure, but with the targets themselves. The objective of this narrative review is to show new targets in DBS surgery as well as new technologies that are under study and have shown promising results to date. The aim is to give an overview of these new targets, as well as their limitations, and describe the current studies in this research field in order to review ongoing research that will probably become effective and routine treatments for PD in the near future. |
format | Online Article Text |
id | pubmed-9321220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93212202022-07-27 New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review Montemurro, Nicola Aliaga, Nelida Graff, Pablo Escribano, Amanda Lizana, Jafeth Int J Environ Res Public Health Commentary Parkinson’s disease (PD) is a progressive neurodegenerative disease, whose main neuropathological finding is pars compacta degeneration due to the accumulation of Lewy bodies and Lewy neurites, and subsequent dopamine depletion. This leads to an increase in the activity of the subthalamic nucleus (STN) and the internal globus pallidus (GPi). Understanding functional anatomy is the key to understanding and developing new targets and new technologies that could potentially improve motor and non-motor symptoms in PD. Currently, the classical targets are insufficient to improve the entire wide spectrum of symptoms in PD (especially non-dopaminergic ones) and none are free of the side effects which are not only associated with the procedure, but with the targets themselves. The objective of this narrative review is to show new targets in DBS surgery as well as new technologies that are under study and have shown promising results to date. The aim is to give an overview of these new targets, as well as their limitations, and describe the current studies in this research field in order to review ongoing research that will probably become effective and routine treatments for PD in the near future. MDPI 2022-07-20 /pmc/articles/PMC9321220/ /pubmed/35886651 http://dx.doi.org/10.3390/ijerph19148799 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Montemurro, Nicola Aliaga, Nelida Graff, Pablo Escribano, Amanda Lizana, Jafeth New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title | New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title_full | New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title_fullStr | New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title_full_unstemmed | New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title_short | New Targets and New Technologies in the Treatment of Parkinson’s Disease: A Narrative Review |
title_sort | new targets and new technologies in the treatment of parkinson’s disease: a narrative review |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321220/ https://www.ncbi.nlm.nih.gov/pubmed/35886651 http://dx.doi.org/10.3390/ijerph19148799 |
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