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Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances

It is common for women to undergo orthodontic treatment during pregnancy, especially through the use of fixed orthodontic devices. In changing the oral microbiome profile, it is crucial to increase the immune responses of pregnant women using fixed orthodontics; however, changes in the microbiomes o...

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Autores principales: Kurniawan, Fajar Kusuma Dwi, Roestamadji, Retno Indrawati, Takahashi, Nobuhiro, Tedjosasongko, Udijanto, Narmada, Ida Bagus, Surboyo, Meircurius Dwi Condro, Diyatri, Indeswati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321247/
https://www.ncbi.nlm.nih.gov/pubmed/35877392
http://dx.doi.org/10.3390/dj10070118
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author Kurniawan, Fajar Kusuma Dwi
Roestamadji, Retno Indrawati
Takahashi, Nobuhiro
Tedjosasongko, Udijanto
Narmada, Ida Bagus
Surboyo, Meircurius Dwi Condro
Diyatri, Indeswati
author_facet Kurniawan, Fajar Kusuma Dwi
Roestamadji, Retno Indrawati
Takahashi, Nobuhiro
Tedjosasongko, Udijanto
Narmada, Ida Bagus
Surboyo, Meircurius Dwi Condro
Diyatri, Indeswati
author_sort Kurniawan, Fajar Kusuma Dwi
collection PubMed
description It is common for women to undergo orthodontic treatment during pregnancy, especially through the use of fixed orthodontic devices. In changing the oral microbiome profile, it is crucial to increase the immune responses of pregnant women using fixed orthodontics; however, changes in the microbiomes of pregnant women with orthodontic appliances can be adjusted. Therefore, we aimed to conduct research on the oral cavity microbiome profiles, specifically IL-6 and TNF-α, of pregnant women using fixed orthodontic appliances. We proposed an observational analysis of 30 third-trimester pregnant women. OHI-S was recorded, saliva collection was performed using the passive drool method for IL-6 and TNF-α, and analysis and mucosal swabs were used to determine the oral microbiome profile. Kruskal–Wallis and post hoc Bonferroni tests were used to identify any significant differences with values of p < 0.05. Of these pregnant women, those with orthodontic appliances developed 10 types of bacteria at similar levels (>80%) from the genera Streptococcus, Lactobacillus, and Veillonella. There was no difference between the oral microbiomes of the control group and the pregnant women with a history of orthodontic appliance use. While the level of TNF-α in the women with orthodontic appliances was higher compared with the control group who had never used orthodontic appliances (p < 0.05), there was no difference in the IL-6 levels. The IL-6 and microbiome profile produced normal results, so the use of orthodontic appliances during pregnancy should be allowed with conditions. Pregnant women with orthodontic appliances must keep the oral cavity clean and their appliances well-maintained to avoid oral problems.
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spelling pubmed-93212472022-07-27 Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances Kurniawan, Fajar Kusuma Dwi Roestamadji, Retno Indrawati Takahashi, Nobuhiro Tedjosasongko, Udijanto Narmada, Ida Bagus Surboyo, Meircurius Dwi Condro Diyatri, Indeswati Dent J (Basel) Article It is common for women to undergo orthodontic treatment during pregnancy, especially through the use of fixed orthodontic devices. In changing the oral microbiome profile, it is crucial to increase the immune responses of pregnant women using fixed orthodontics; however, changes in the microbiomes of pregnant women with orthodontic appliances can be adjusted. Therefore, we aimed to conduct research on the oral cavity microbiome profiles, specifically IL-6 and TNF-α, of pregnant women using fixed orthodontic appliances. We proposed an observational analysis of 30 third-trimester pregnant women. OHI-S was recorded, saliva collection was performed using the passive drool method for IL-6 and TNF-α, and analysis and mucosal swabs were used to determine the oral microbiome profile. Kruskal–Wallis and post hoc Bonferroni tests were used to identify any significant differences with values of p < 0.05. Of these pregnant women, those with orthodontic appliances developed 10 types of bacteria at similar levels (>80%) from the genera Streptococcus, Lactobacillus, and Veillonella. There was no difference between the oral microbiomes of the control group and the pregnant women with a history of orthodontic appliance use. While the level of TNF-α in the women with orthodontic appliances was higher compared with the control group who had never used orthodontic appliances (p < 0.05), there was no difference in the IL-6 levels. The IL-6 and microbiome profile produced normal results, so the use of orthodontic appliances during pregnancy should be allowed with conditions. Pregnant women with orthodontic appliances must keep the oral cavity clean and their appliances well-maintained to avoid oral problems. MDPI 2022-07-01 /pmc/articles/PMC9321247/ /pubmed/35877392 http://dx.doi.org/10.3390/dj10070118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kurniawan, Fajar Kusuma Dwi
Roestamadji, Retno Indrawati
Takahashi, Nobuhiro
Tedjosasongko, Udijanto
Narmada, Ida Bagus
Surboyo, Meircurius Dwi Condro
Diyatri, Indeswati
Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title_full Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title_fullStr Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title_full_unstemmed Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title_short Oral Microbiome Profiles and Inflammation in Pregnant Women Who Used Orthodontic Appliances
title_sort oral microbiome profiles and inflammation in pregnant women who used orthodontic appliances
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321247/
https://www.ncbi.nlm.nih.gov/pubmed/35877392
http://dx.doi.org/10.3390/dj10070118
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