Mono and Multiple Tumor-Targeting Ligand-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Enhanced Tumor Imaging and Blood Circulation

Hydrophilic and biocompatible PAA-coated ultrasmall Gd(2)O(3) nanoparticles (d(avg) = 1.7 nm) were synthesized and conjugated with tumor-targeting ligands, i.e., cyclic arginylglycylaspartic acid (cRGD) and/or folic acid (FA). FA-PAA-Gd(2)O(3) and cRGD/FA-PAA-Gd(2)O(3) nanoparticles were successfull...

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Detalles Bibliográficos
Autores principales: Ho, Son Long, Yue, Huan, Lee, Sangyeol, Tegafaw, Tirusew, Ahmad, Mohammad Yaseen, Liu, Shuwen, Saidi, Abdullah Khamis Ali Al, Zhao, Dejun, Liu, Ying, Nam, Sung-Wook, Chae, Kwon Seok, Chang, Yongmin, Lee, Gang Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321250/
https://www.ncbi.nlm.nih.gov/pubmed/35890353
http://dx.doi.org/10.3390/pharmaceutics14071458
Descripción
Sumario:Hydrophilic and biocompatible PAA-coated ultrasmall Gd(2)O(3) nanoparticles (d(avg) = 1.7 nm) were synthesized and conjugated with tumor-targeting ligands, i.e., cyclic arginylglycylaspartic acid (cRGD) and/or folic acid (FA). FA-PAA-Gd(2)O(3) and cRGD/FA-PAA-Gd(2)O(3) nanoparticles were successfully applied in U87MG tumor-bearing mice for tumor imaging using T(1) magnetic resonance imaging (MRI). cRGD/FA-PAA-Gd(2)O(3) nanoparticles with multiple tumor-targeting ligands exhibited higher contrasts at the tumor site than FA-PAA-Gd(2)O(3) nanoparticles with mono tumor-targeting ligands. In addition, the cRGD/FA-PAA-Gd(2)O(3) nanoparticles exhibited higher contrasts in all organs, especially the aorta, compared with those of the FA-PAA-Gd(2)O(3) nanoparticles, because of the blood cell hitchhiking effect of cRGD in the cRGD/FA-PAA-Gd(2)O(3) nanoparticles, which prolonged their circulation in the blood.

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