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Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers

Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response o...

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Autores principales: Zurac, Sabina, Vladan, Cristian, Dinca, Octavian, Constantin, Carolina, Neagu, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321272/
https://www.ncbi.nlm.nih.gov/pubmed/35882871
http://dx.doi.org/10.1038/s41598-022-16759-2
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author Zurac, Sabina
Vladan, Cristian
Dinca, Octavian
Constantin, Carolina
Neagu, Monica
author_facet Zurac, Sabina
Vladan, Cristian
Dinca, Octavian
Constantin, Carolina
Neagu, Monica
author_sort Zurac, Sabina
collection PubMed
description Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response of specific IgG and IgA antibodies upon vaccination, during the second year of pandemic and evaluating the booster shot with the same vaccine type. A group of 103 HCW with documented exposure to the virus were monitored for specific IgG and IgA levels prior to vaccination, after the first vaccination round, during the following 8 months and after the booster shot with the same vaccine type. After 8 months post-vaccination the humoral response in both IgG and IgA decreased, 2.4 times for IgG, and 2.7 times for IgA. Although the antibodies levels significantly decreased, no documented infection was registered in the group. After the booster shot, the entire group, displayed IgG increased levels, immediately after booster followed by the increase in specific IgA. IgG levels post-second round of vaccination are statistically higher compared to the first round, while IgA is restored at the same levels. Within the vaccination or booster routine for a multiple waves’ pandemic that is generating new virus variants, populational immunity remains an important issue for future implementation of prevention/control measures.
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spelling pubmed-93212722022-07-27 Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers Zurac, Sabina Vladan, Cristian Dinca, Octavian Constantin, Carolina Neagu, Monica Sci Rep Article Waning of the immune response upon vaccination in SARS-CoV-2 infection is an important subject of evaluation in this pandemic, mostly in healthcare workers (HCW) that are constantly in contact with infected samples and patients. Therefore, our study aimed to establish the specific humoral response of specific IgG and IgA antibodies upon vaccination, during the second year of pandemic and evaluating the booster shot with the same vaccine type. A group of 103 HCW with documented exposure to the virus were monitored for specific IgG and IgA levels prior to vaccination, after the first vaccination round, during the following 8 months and after the booster shot with the same vaccine type. After 8 months post-vaccination the humoral response in both IgG and IgA decreased, 2.4 times for IgG, and 2.7 times for IgA. Although the antibodies levels significantly decreased, no documented infection was registered in the group. After the booster shot, the entire group, displayed IgG increased levels, immediately after booster followed by the increase in specific IgA. IgG levels post-second round of vaccination are statistically higher compared to the first round, while IgA is restored at the same levels. Within the vaccination or booster routine for a multiple waves’ pandemic that is generating new virus variants, populational immunity remains an important issue for future implementation of prevention/control measures. Nature Publishing Group UK 2022-07-26 /pmc/articles/PMC9321272/ /pubmed/35882871 http://dx.doi.org/10.1038/s41598-022-16759-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zurac, Sabina
Vladan, Cristian
Dinca, Octavian
Constantin, Carolina
Neagu, Monica
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title_full Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title_fullStr Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title_full_unstemmed Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title_short Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers
title_sort immunogenicity evaluation after bnt162b2 booster vaccination in healthcare workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321272/
https://www.ncbi.nlm.nih.gov/pubmed/35882871
http://dx.doi.org/10.1038/s41598-022-16759-2
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