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Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions

Hemorrhagic toxin (TcsH) is an important exotoxin produced by Paeniclostridium sordellii, but the exact role of TcsH in the pathogenesis remains unclear, partly due to the lack of knowledge of host receptor(s). Here, we carried out two genome-wide CRISPR/Cas9 screens parallelly with TcsH and identif...

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Detalles Bibliográficos
Autores principales:	Li, Xingxing, He, Liuqing, Luo, Jianhua, Zheng, Yangling, Zhou, Yao, Li, Danyang, Zhang, Yuanyuan, Pan, Zhenrui, Li, Yanyan, Tao, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321280/ https://www.ncbi.nlm.nih.gov/pubmed/35882856 http://dx.doi.org/10.1038/s41467-022-31994-x

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