Cargando…

Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope

The study was designed to explore whether 24-hour urinary sodium excretion could predict the therapeutic effectiveness of oral rehydration saline in pediatric cases of vasovagal syncope. Eighty children suffering from vasovagal syncope with oral rehydration saline treatment in Department of Pediatri...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Xiaojuan, Tao, Chunyan, Wang, Yaru, Sun, Yan, Zhang, Qingyou, Zhang, Chunyu, Liu, Ping, Wang, Yuli, Liao, Ying, Du, Junbao, Jin, Hongfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321383/
https://www.ncbi.nlm.nih.gov/pubmed/35883976
http://dx.doi.org/10.3390/children9070992
_version_ 1784756031489835008
author Du, Xiaojuan
Tao, Chunyan
Wang, Yaru
Sun, Yan
Zhang, Qingyou
Zhang, Chunyu
Liu, Ping
Wang, Yuli
Liao, Ying
Du, Junbao
Jin, Hongfang
author_facet Du, Xiaojuan
Tao, Chunyan
Wang, Yaru
Sun, Yan
Zhang, Qingyou
Zhang, Chunyu
Liu, Ping
Wang, Yuli
Liao, Ying
Du, Junbao
Jin, Hongfang
author_sort Du, Xiaojuan
collection PubMed
description The study was designed to explore whether 24-hour urinary sodium excretion could predict the therapeutic effectiveness of oral rehydration saline in pediatric cases of vasovagal syncope. Eighty children suffering from vasovagal syncope with oral rehydration saline treatment in Department of Pediatrics, Peking University First Hospital, China, were recruited into the study. They were followed up for 3 (2, 3) months after treatment. Pre-treatment demographic, clinical, head-up tilt test-based hemodynamic and laboratory variables were compared between responders and non-responders. After univariate analysis, variables with p value < 0.05 in the comparison between responders and non-responders were further analyzed by binary logistic regression analysis. Receiver operating characteristic (ROC) curve was conducted to assess the value in predicting effectiveness of oral rehydration saline treatment. The results showed that 33 cases were responders, and 47 were non-responders. Blood sodium (138 ± 2 mmol/L vs. 139 ± 2 mmol/L, p < 0.05) and pre-treatment 24-hour urinary sodium excretion (74 ± 29 mmol/24 h vs. 109 (93, 141) mmol/24 h, p < 0.001) were lower in responders than in non-responders. The baseline 24-hour urinary sodium excretion was positively correlated to the duration from tilting to the positive response appearance in head-up tilt test (r = 0.289, p < 0.01). The cut-off value of baseline 24-hour urinary sodium excretion of the therapeutic effectiveness of oral rehydration saline on vasovagal syncope cases was 83 mmol/24 h, yielding a sensitivity of 87% and a specificity of 73% with AUC of 0.842 (p < 0.001). In conclusion, 24-hour urinary sodium excretion could be a useful biomarker to predict the therapeutic response to oral rehydration saline in pediatric cases of vasovagal syncope.
format Online
Article
Text
id pubmed-9321383
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93213832022-07-27 Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope Du, Xiaojuan Tao, Chunyan Wang, Yaru Sun, Yan Zhang, Qingyou Zhang, Chunyu Liu, Ping Wang, Yuli Liao, Ying Du, Junbao Jin, Hongfang Children (Basel) Article The study was designed to explore whether 24-hour urinary sodium excretion could predict the therapeutic effectiveness of oral rehydration saline in pediatric cases of vasovagal syncope. Eighty children suffering from vasovagal syncope with oral rehydration saline treatment in Department of Pediatrics, Peking University First Hospital, China, were recruited into the study. They were followed up for 3 (2, 3) months after treatment. Pre-treatment demographic, clinical, head-up tilt test-based hemodynamic and laboratory variables were compared between responders and non-responders. After univariate analysis, variables with p value < 0.05 in the comparison between responders and non-responders were further analyzed by binary logistic regression analysis. Receiver operating characteristic (ROC) curve was conducted to assess the value in predicting effectiveness of oral rehydration saline treatment. The results showed that 33 cases were responders, and 47 were non-responders. Blood sodium (138 ± 2 mmol/L vs. 139 ± 2 mmol/L, p < 0.05) and pre-treatment 24-hour urinary sodium excretion (74 ± 29 mmol/24 h vs. 109 (93, 141) mmol/24 h, p < 0.001) were lower in responders than in non-responders. The baseline 24-hour urinary sodium excretion was positively correlated to the duration from tilting to the positive response appearance in head-up tilt test (r = 0.289, p < 0.01). The cut-off value of baseline 24-hour urinary sodium excretion of the therapeutic effectiveness of oral rehydration saline on vasovagal syncope cases was 83 mmol/24 h, yielding a sensitivity of 87% and a specificity of 73% with AUC of 0.842 (p < 0.001). In conclusion, 24-hour urinary sodium excretion could be a useful biomarker to predict the therapeutic response to oral rehydration saline in pediatric cases of vasovagal syncope. MDPI 2022-07-01 /pmc/articles/PMC9321383/ /pubmed/35883976 http://dx.doi.org/10.3390/children9070992 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Du, Xiaojuan
Tao, Chunyan
Wang, Yaru
Sun, Yan
Zhang, Qingyou
Zhang, Chunyu
Liu, Ping
Wang, Yuli
Liao, Ying
Du, Junbao
Jin, Hongfang
Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title_full Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title_fullStr Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title_full_unstemmed Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title_short Twenty-Four-Hour Urinary Sodium Excretion Predicts Therapeutic Effectiveness of Oral Rehydration Saline in Pediatric Vasovagal Syncope
title_sort twenty-four-hour urinary sodium excretion predicts therapeutic effectiveness of oral rehydration saline in pediatric vasovagal syncope
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321383/
https://www.ncbi.nlm.nih.gov/pubmed/35883976
http://dx.doi.org/10.3390/children9070992
work_keys_str_mv AT duxiaojuan twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT taochunyan twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT wangyaru twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT sunyan twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT zhangqingyou twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT zhangchunyu twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT liuping twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT wangyuli twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT liaoying twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT dujunbao twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope
AT jinhongfang twentyfourhoururinarysodiumexcretionpredictstherapeuticeffectivenessoforalrehydrationsalineinpediatricvasovagalsyncope