The Role and Therapeutic Potential of the Integrated Stress Response in Amyotrophic Lateral Sclerosis

In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical and spinal cord motor neurons triggers the activation of the integrated stress response (ISR), an intracellular signaling pathway that remodels translation and promotes a gene expression program aimed at co...

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Detalles Bibliográficos
Autores principales: Marlin, Elías, Viu-Idocin, Cristina, Arrasate, Montserrat, Aragón, Tomás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321386/
https://www.ncbi.nlm.nih.gov/pubmed/35887167
http://dx.doi.org/10.3390/ijms23147823

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