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Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis

BACKGROUND: Although programmed cell death-ligand 1 (PD-L1) has been recognized as a potential marker in several cancers, the relationship between PD-L1 expression and survival in patients with salivary gland carcinoma (SGC) has remained unclear. We aimed to evaluate the association of PD-L1 express...

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Autores principales: Wu, Limeng, Jiang, Canhua, Zhu, Zhihui, Sun, Yao, Zhang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321421/
https://www.ncbi.nlm.nih.gov/pubmed/35881656
http://dx.doi.org/10.1371/journal.pone.0272080
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author Wu, Limeng
Jiang, Canhua
Zhu, Zhihui
Sun, Yao
Zhang, Tao
author_facet Wu, Limeng
Jiang, Canhua
Zhu, Zhihui
Sun, Yao
Zhang, Tao
author_sort Wu, Limeng
collection PubMed
description BACKGROUND: Although programmed cell death-ligand 1 (PD-L1) has been recognized as a potential marker in several cancers, the relationship between PD-L1 expression and survival in patients with salivary gland carcinoma (SGC) has remained unclear. We aimed to evaluate the association of PD-L1 expression with clinicopathological features and prognosis in SGC patients. METHODS: The databases Ovid Medline, PubMed, Scopus, and EMBASE were searched for relevant studies that detected PD-L1 expression in SGC. The meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the reporting recommendations for tumor marker prognostic studies (REMARK) was used to assess the quality of research eligible for this meta-analysis. Included studies were assessed using the Quality in Prognosis Studies (QUIPS) tool. Odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the correlation between PD-L1 expression and clinicopathological features. Hazard ratios (HRs) with 95% CI were applied to assess the association between PD-L1 expression and survival outcomes of patients. RESULTS: A total of ten studies (including 952 patients with SGC) were evaluated. The meta-analysis showed that positive PD-L1 expression in SGC was significantly associated with male patients, older age, Tumor stage, lymph node metastasis, high pathological grade, and non-adenoid cystic carcinoma subtype. The pooled data demonstrated that high PD-L1 expression was associated with poor overall survival and disease-free survival. There was no significant correlation between PD-L1 expression and progression-free survival or disease-specific survival of SGC patients. CONCLUSION: According to the meta-analysis, positive PD-L1 expression may play an important role as an effective marker of poor prognosis in patients with SGC. However, large-scale, prospective investigations are still needed to confirm the findings. The assessment of PD-L1 expression may aid in the personalized management of SGC.
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spelling pubmed-93214212022-07-27 Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis Wu, Limeng Jiang, Canhua Zhu, Zhihui Sun, Yao Zhang, Tao PLoS One Research Article BACKGROUND: Although programmed cell death-ligand 1 (PD-L1) has been recognized as a potential marker in several cancers, the relationship between PD-L1 expression and survival in patients with salivary gland carcinoma (SGC) has remained unclear. We aimed to evaluate the association of PD-L1 expression with clinicopathological features and prognosis in SGC patients. METHODS: The databases Ovid Medline, PubMed, Scopus, and EMBASE were searched for relevant studies that detected PD-L1 expression in SGC. The meta-analysis was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), and the reporting recommendations for tumor marker prognostic studies (REMARK) was used to assess the quality of research eligible for this meta-analysis. Included studies were assessed using the Quality in Prognosis Studies (QUIPS) tool. Odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the correlation between PD-L1 expression and clinicopathological features. Hazard ratios (HRs) with 95% CI were applied to assess the association between PD-L1 expression and survival outcomes of patients. RESULTS: A total of ten studies (including 952 patients with SGC) were evaluated. The meta-analysis showed that positive PD-L1 expression in SGC was significantly associated with male patients, older age, Tumor stage, lymph node metastasis, high pathological grade, and non-adenoid cystic carcinoma subtype. The pooled data demonstrated that high PD-L1 expression was associated with poor overall survival and disease-free survival. There was no significant correlation between PD-L1 expression and progression-free survival or disease-specific survival of SGC patients. CONCLUSION: According to the meta-analysis, positive PD-L1 expression may play an important role as an effective marker of poor prognosis in patients with SGC. However, large-scale, prospective investigations are still needed to confirm the findings. The assessment of PD-L1 expression may aid in the personalized management of SGC. Public Library of Science 2022-07-26 /pmc/articles/PMC9321421/ /pubmed/35881656 http://dx.doi.org/10.1371/journal.pone.0272080 Text en © 2022 Wu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wu, Limeng
Jiang, Canhua
Zhu, Zhihui
Sun, Yao
Zhang, Tao
Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title_full Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title_fullStr Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title_full_unstemmed Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title_short Prognostic role of PD-L1 expression in patients with salivary gland carcinoma: A systematic review and meta-analysis
title_sort prognostic role of pd-l1 expression in patients with salivary gland carcinoma: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321421/
https://www.ncbi.nlm.nih.gov/pubmed/35881656
http://dx.doi.org/10.1371/journal.pone.0272080
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