Reliable Functionalization of 5,6‐Fused Bicyclic N‐Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics

DFT‐calculations allow prediction of the reactivity of uncommon N‐heterocyclic scaffolds of pyrazolo[1,5‐a]pyrimidines and imidazo[1,2‐b]pyridazines and considerably facilitate their functionalization. The derivatization of these N‐heterocycles was realized using Grignard reagents for nucleophilic a...

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Detalles Bibliográficos
Autores principales: Kumar Rout, Saroj, Kastrati, Agonist, Jangra, Harish, Schwärzer, Kuno, Sunagatullina, Alisa S., Garny, Maximilien, Lima, Fabio, Brocklehurst, Cara E., Karaghiosoff, Konstantin, Zipse, Hendrik, Knochel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321601/
https://www.ncbi.nlm.nih.gov/pubmed/35384103
http://dx.doi.org/10.1002/chem.202200733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321601/
https://www.ncbi.nlm.nih.gov/pubmed/35384103
http://dx.doi.org/10.1002/chem.202200733

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