Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T Cell–mediated Antitumor Activity in Mice

Tumor-associated macrophages (TAM) promote tumor survival, angiogenesis, and metastases. Although they express MHC class II molecules, little is known about their ability to present tumor antigens to tumor-infiltrating CD4 T cells, and the consequences of such presentation. To answer these questions...

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Detalles Bibliográficos
Autores principales: Perez-Diez, Ainhoa, Liu, Xiangdong, Matzinger, Polly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321644/
https://www.ncbi.nlm.nih.gov/pubmed/35903540
http://dx.doi.org/10.1158/2767-9764.CRC-22-0052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321644/
https://www.ncbi.nlm.nih.gov/pubmed/35903540
http://dx.doi.org/10.1158/2767-9764.CRC-22-0052

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