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Tailored Pyridoxal Probes Unravel Novel Cofactor‐Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens

Unprecedented bacterial targets are urgently needed to overcome the resistance crisis. Herein we systematically mine pyridoxal phosphate‐dependent enzymes (PLP‐DEs) in bacteria to focus on a target class which is involved in crucial metabolic processes. For this, we tailored eight pyridoxal (PL) pro...

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Detalles Bibliográficos
Autores principales:	Pfanzelt, Martin, Maher, Thomas E., Absmeier, Ramona M., Schwarz, Markus, Sieber, Stephan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321722/ https://www.ncbi.nlm.nih.gov/pubmed/35199904 http://dx.doi.org/10.1002/anie.202117724

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