Metabolic Profiling of Rheumatoid Arthritis Neutrophils Reveals Altered Energy Metabolism That Is Not Affected by JAK Inhibition

Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function can be modulated by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically eff...

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Detalles Bibliográficos
Autores principales: Chokesuwattanaskul, Susama, Fresneda Alarcon, Michele, Mangalakumaran, Sangeetha, Grosman, Rudi, Cross, Andrew L., Chapman, Elinor A., Mason, David, Moots, Robert J., Phelan, Marie M., Wright, Helen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321732/
https://www.ncbi.nlm.nih.gov/pubmed/35888774
http://dx.doi.org/10.3390/metabo12070650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321732/
https://www.ncbi.nlm.nih.gov/pubmed/35888774
http://dx.doi.org/10.3390/metabo12070650

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