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Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice

BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in alcohol metabolism. The ALDH2*2 mutations are found in approximately 45% of East Asians, with 40% being heterozygous (HE) ALDH2*1/*2 and 5% homozygous (HO) ALDH2*2/*2. Studies have shown that HO mice lack cardioprotective...

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Detalles Bibliográficos
Autores principales:	Hu, Qinfeng, Chen, Hang, Shen, Cheng, Zhang, Beijian, Weng, Xinyu, Sun, Xiaolei, Liu, Jin, Dong, Zhen, Hu, Kai, Ge, Junbo, Sun, Aijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Cell and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321750/ https://www.ncbi.nlm.nih.gov/pubmed/35315077 http://dx.doi.org/10.1111/acer.14811

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