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Antiviral Cyclopropane Acids from Deep-Sea-Derived Fungus Aspergillus sydowii

Four novel monocyclic cyclopropane acids, namely, sydocyclopropanes A–D (1–4), along with one known congener hamavellone B (5), were isolated from the Aspergillus sydowii MCCC 3A00324 fungus, which was isolated from the deep-sea sediment. The gross structures of novel compounds were established by d...

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Detalles Bibliográficos
Autores principales: Niu, Siwen, Huang, Shuhuan, Hong, Bihong, Huang, Qixi, Liu, Xiupian, Shao, Zongze, Zhang, Gaiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321810/
https://www.ncbi.nlm.nih.gov/pubmed/35877703
http://dx.doi.org/10.3390/md20070410
Descripción
Sumario:Four novel monocyclic cyclopropane acids, namely, sydocyclopropanes A–D (1–4), along with one known congener hamavellone B (5), were isolated from the Aspergillus sydowii MCCC 3A00324 fungus, which was isolated from the deep-sea sediment. The gross structures of novel compounds were established by detailed analyses of the spectroscopic data (HRESIMS and NMR spectra), and their absolute configurations were resolved on the basis of the quantum chemical calculations of ECD and NMR data, in association with DP4+ probability analyses. Sydocyclopropanes A–D, featuring the 1,1,2,3-tetrasubstituted cyclopropane nucleus with different lengthy alkyl side chains, were discovered in nature for the first time. All compounds exhibited antiviral activities against A/WSN/33 (H1N1), with IC(50) values ranging from 26.7 to 77.2 μM, of which compound 1 exhibited a moderate inhibitory effect (IC(50) = 26.7 μM).