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Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings

Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in accelerating wound healing, there are minimal data directly com...

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Autores principales: Chen, Kellen, Sivaraj, Dharshan, Davitt, Michael F., Leeolou, Melissa C., Henn, Dominic, Steele, Sydney R., Huskins, Savana L., Trotsyuk, Artem A., Kussie, Hudson C., Greco, Autumn H., Padmanabhan, Jagannath, Perrault, David P., Zamaleeva, Alsu I., Longaker, Michael T., Gurtner, Geoffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321852/
https://www.ncbi.nlm.nih.gov/pubmed/35384131
http://dx.doi.org/10.1111/wrr.13012
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author Chen, Kellen
Sivaraj, Dharshan
Davitt, Michael F.
Leeolou, Melissa C.
Henn, Dominic
Steele, Sydney R.
Huskins, Savana L.
Trotsyuk, Artem A.
Kussie, Hudson C.
Greco, Autumn H.
Padmanabhan, Jagannath
Perrault, David P.
Zamaleeva, Alsu I.
Longaker, Michael T.
Gurtner, Geoffrey C.
author_facet Chen, Kellen
Sivaraj, Dharshan
Davitt, Michael F.
Leeolou, Melissa C.
Henn, Dominic
Steele, Sydney R.
Huskins, Savana L.
Trotsyuk, Artem A.
Kussie, Hudson C.
Greco, Autumn H.
Padmanabhan, Jagannath
Perrault, David P.
Zamaleeva, Alsu I.
Longaker, Michael T.
Gurtner, Geoffrey C.
author_sort Chen, Kellen
collection PubMed
description Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in accelerating wound healing, there are minimal data directly comparing different hydrogel material compositions. In this study, we utilized a splinted excisional wound model that recapitulates human‐like wound healing in mice and treated wounds with three different collagen hydrogel dressings. We assessed the feasibility of applying each dressing and performed histologic and histopathologic analysis on the explanted scar tissues to assess variations in collagen architecture and alignment, as well as the tissue response. Our data indicate that the material properties of hydrogel dressings can significantly influence healing time, cellular response, and resulting architecture of healed scars. Specifically, our pullulan‐collagen hydrogel dressing accelerated wound closure and promoted healed tissue with less dense, more randomly aligned, and shorter collagen fibres. Further understanding of how hydrogel properties affect the healing and resulting scar architecture of wounds may lead to novel insights and further optimization of the material properties of wound dressings.
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spelling pubmed-93218522022-07-30 Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings Chen, Kellen Sivaraj, Dharshan Davitt, Michael F. Leeolou, Melissa C. Henn, Dominic Steele, Sydney R. Huskins, Savana L. Trotsyuk, Artem A. Kussie, Hudson C. Greco, Autumn H. Padmanabhan, Jagannath Perrault, David P. Zamaleeva, Alsu I. Longaker, Michael T. Gurtner, Geoffrey C. Wound Repair Regen Original Research‐Basic Science Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury. While most studies have focused on the benefits of hydrogels in accelerating wound healing, there are minimal data directly comparing different hydrogel material compositions. In this study, we utilized a splinted excisional wound model that recapitulates human‐like wound healing in mice and treated wounds with three different collagen hydrogel dressings. We assessed the feasibility of applying each dressing and performed histologic and histopathologic analysis on the explanted scar tissues to assess variations in collagen architecture and alignment, as well as the tissue response. Our data indicate that the material properties of hydrogel dressings can significantly influence healing time, cellular response, and resulting architecture of healed scars. Specifically, our pullulan‐collagen hydrogel dressing accelerated wound closure and promoted healed tissue with less dense, more randomly aligned, and shorter collagen fibres. Further understanding of how hydrogel properties affect the healing and resulting scar architecture of wounds may lead to novel insights and further optimization of the material properties of wound dressings. John Wiley & Sons, Inc. 2022-04-18 2022 /pmc/articles/PMC9321852/ /pubmed/35384131 http://dx.doi.org/10.1111/wrr.13012 Text en © 2022 The Authors. Wound Repair and Regeneration published by Wiley Periodicals LLC on behalf of The Wound Healing Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research‐Basic Science
Chen, Kellen
Sivaraj, Dharshan
Davitt, Michael F.
Leeolou, Melissa C.
Henn, Dominic
Steele, Sydney R.
Huskins, Savana L.
Trotsyuk, Artem A.
Kussie, Hudson C.
Greco, Autumn H.
Padmanabhan, Jagannath
Perrault, David P.
Zamaleeva, Alsu I.
Longaker, Michael T.
Gurtner, Geoffrey C.
Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title_full Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title_fullStr Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title_full_unstemmed Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title_short Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
title_sort pullulan‐collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings
topic Original Research‐Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321852/
https://www.ncbi.nlm.nih.gov/pubmed/35384131
http://dx.doi.org/10.1111/wrr.13012
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