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Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment

Aim: To identify the predictors of in-hospital mortality in patients with coronavirus disease of 2019 (COVID-19) and acute renal impairment (ARI) or chronic kidney disease (CKD), and to evaluate the performance and inter-reader concordance of chest CT total severity scores (TSSs). Methods: This retr...

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Autores principales: Tharwat, Samar, Saleh, Gehad A., Saleh, Marwa, Mounir, Ahmad M., Abdelzaher, Dina G., Salah, Ahmed M, Nassar, Mohammed Kamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321924/
https://www.ncbi.nlm.nih.gov/pubmed/35885435
http://dx.doi.org/10.3390/diagnostics12071529
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author Tharwat, Samar
Saleh, Gehad A.
Saleh, Marwa
Mounir, Ahmad M.
Abdelzaher, Dina G.
Salah, Ahmed M
Nassar, Mohammed Kamal
author_facet Tharwat, Samar
Saleh, Gehad A.
Saleh, Marwa
Mounir, Ahmad M.
Abdelzaher, Dina G.
Salah, Ahmed M
Nassar, Mohammed Kamal
author_sort Tharwat, Samar
collection PubMed
description Aim: To identify the predictors of in-hospital mortality in patients with coronavirus disease of 2019 (COVID-19) and acute renal impairment (ARI) or chronic kidney disease (CKD), and to evaluate the performance and inter-reader concordance of chest CT total severity scores (TSSs). Methods: This retrospective single-center study was conducted on symptomatic COVID-19 patients with renal impairment (either acute or chronic) and a serum creatinine of >2 mg/dL at the time of admission. The patients’ demographic characteristics, clinical data, and laboratory data were extracted from the clinical computerized medical records. All chest CT images obtained at the time of hospital admission were analyzed. Two radiologists independently assessed the pulmonary abnormalities and scored the severity using CT chest total severity score (TSS). Univariate logistic regression analysis was used to determine factors associated with in-hospital mortality. A receiver operating characteristic (ROC) curve analysis was performed for the TSS in order to identify the cut-off point that predicts mortality. Bland–Altman plots were used to evaluate agreement between the two radiologists assessing TSS. Results: A total of 100 patients were included, with a mean age of 60 years, 54 were males, 53 had ARI, and 47 had CKD. In terms of in-hospital mortality, 60 patients were classified in the non-survivor group and 40 were classified in the survivor group. The mortality rate was higher for those with ARI compared to those with CKD (p = 0.033). The univariate regression analysis showed an increasing odds of in-hospital mortality associated with higher respiratory rate (OR 1.149, 95% CI 1.057–1.248, p = 0.001), total bilirubin (OR 2.532, 95% CI 1.099–5.836, p = 0.029), lactate dehydrogenase (LDH) (OR 1.001, 95% CI 1.000–1.003, p = 0.018), CRP (OR 1.010, 95% CI 1.002–1.017, p = 0.012), invasive mechanical ventilation (MV) (OR 7.667, 95% CI 2.118–27.755, p = 0.002), a predominant pattern of pulmonary consolidation (OR 21.714, 95% CI 4.799–98.261, p < 0.001), and high TSS (OR 2.082, 95% CI 1.579–2.745, p < 0.001). The optimum cut-off value of TSS used to predict in-hospital mortality was 8.5 with a sensitivity of 86.7% and a specificity of 87.5%. There was excellent interobserver agreement (ICC > 0.9) between the two independent radiologists in their quantitative assessment of pulmonary changes using TSS. Conclusions: In-hospital mortality is high in COVID-19 patients with ARI/CKD, especially for those with ARI. High serum bilirubin, a predominant pattern of pulmonary consolidation, and TSS are the most significant predictors of mortality in these patients. Patients with a higher TSS may require more intensive hospital care. TSS is a reliable and helpful auxiliary tool for risk stratification among COVID-19 patients with ARI/CKD.
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spelling pubmed-93219242022-07-27 Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment Tharwat, Samar Saleh, Gehad A. Saleh, Marwa Mounir, Ahmad M. Abdelzaher, Dina G. Salah, Ahmed M Nassar, Mohammed Kamal Diagnostics (Basel) Article Aim: To identify the predictors of in-hospital mortality in patients with coronavirus disease of 2019 (COVID-19) and acute renal impairment (ARI) or chronic kidney disease (CKD), and to evaluate the performance and inter-reader concordance of chest CT total severity scores (TSSs). Methods: This retrospective single-center study was conducted on symptomatic COVID-19 patients with renal impairment (either acute or chronic) and a serum creatinine of >2 mg/dL at the time of admission. The patients’ demographic characteristics, clinical data, and laboratory data were extracted from the clinical computerized medical records. All chest CT images obtained at the time of hospital admission were analyzed. Two radiologists independently assessed the pulmonary abnormalities and scored the severity using CT chest total severity score (TSS). Univariate logistic regression analysis was used to determine factors associated with in-hospital mortality. A receiver operating characteristic (ROC) curve analysis was performed for the TSS in order to identify the cut-off point that predicts mortality. Bland–Altman plots were used to evaluate agreement between the two radiologists assessing TSS. Results: A total of 100 patients were included, with a mean age of 60 years, 54 were males, 53 had ARI, and 47 had CKD. In terms of in-hospital mortality, 60 patients were classified in the non-survivor group and 40 were classified in the survivor group. The mortality rate was higher for those with ARI compared to those with CKD (p = 0.033). The univariate regression analysis showed an increasing odds of in-hospital mortality associated with higher respiratory rate (OR 1.149, 95% CI 1.057–1.248, p = 0.001), total bilirubin (OR 2.532, 95% CI 1.099–5.836, p = 0.029), lactate dehydrogenase (LDH) (OR 1.001, 95% CI 1.000–1.003, p = 0.018), CRP (OR 1.010, 95% CI 1.002–1.017, p = 0.012), invasive mechanical ventilation (MV) (OR 7.667, 95% CI 2.118–27.755, p = 0.002), a predominant pattern of pulmonary consolidation (OR 21.714, 95% CI 4.799–98.261, p < 0.001), and high TSS (OR 2.082, 95% CI 1.579–2.745, p < 0.001). The optimum cut-off value of TSS used to predict in-hospital mortality was 8.5 with a sensitivity of 86.7% and a specificity of 87.5%. There was excellent interobserver agreement (ICC > 0.9) between the two independent radiologists in their quantitative assessment of pulmonary changes using TSS. Conclusions: In-hospital mortality is high in COVID-19 patients with ARI/CKD, especially for those with ARI. High serum bilirubin, a predominant pattern of pulmonary consolidation, and TSS are the most significant predictors of mortality in these patients. Patients with a higher TSS may require more intensive hospital care. TSS is a reliable and helpful auxiliary tool for risk stratification among COVID-19 patients with ARI/CKD. MDPI 2022-06-23 /pmc/articles/PMC9321924/ /pubmed/35885435 http://dx.doi.org/10.3390/diagnostics12071529 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tharwat, Samar
Saleh, Gehad A.
Saleh, Marwa
Mounir, Ahmad M.
Abdelzaher, Dina G.
Salah, Ahmed M
Nassar, Mohammed Kamal
Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title_full Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title_fullStr Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title_full_unstemmed Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title_short Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in COVID-19 Patients with Acute and Chronic Renal Impairment
title_sort chest ct total severity score on admission to predict in-hospital mortality in covid-19 patients with acute and chronic renal impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321924/
https://www.ncbi.nlm.nih.gov/pubmed/35885435
http://dx.doi.org/10.3390/diagnostics12071529
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