Cargando…

Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms

Biofilms are part of the natural lifecycle of bacteria and are known to cause chronic infections that are difficult to treat. Most antibiotics are developed and tested against bacteria in the planktonic state and are ineffective against bacterial biofilms. The oxazolidinones, including the last reso...

Descripción completa

Detalles Bibliográficos
Autores principales: Ndukwe, Audrey R. N., Wiedbrauk, Sandra, Boase, Nathan R. B., Fairfull‐Smith, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321984/
https://www.ncbi.nlm.nih.gov/pubmed/35352479
http://dx.doi.org/10.1002/asia.202200201
_version_ 1784756185185910784
author Ndukwe, Audrey R. N.
Wiedbrauk, Sandra
Boase, Nathan R. B.
Fairfull‐Smith, Kathryn E.
author_facet Ndukwe, Audrey R. N.
Wiedbrauk, Sandra
Boase, Nathan R. B.
Fairfull‐Smith, Kathryn E.
author_sort Ndukwe, Audrey R. N.
collection PubMed
description Biofilms are part of the natural lifecycle of bacteria and are known to cause chronic infections that are difficult to treat. Most antibiotics are developed and tested against bacteria in the planktonic state and are ineffective against bacterial biofilms. The oxazolidinones, including the last resort drug linezolid, are one of the main classes of synthetic antibiotics progressed to clinical use in the last 50 years. They have a unique mechanism of action and only develop low levels of resistance in the clinical setting. With the aim of providing insight into strategies to design more potent antibiotic compounds with activity against bacterial biofilms, we review the biofilm activity of clinically approved oxazolidinones and report on structural modifications to oxazolidinones and their delivery systems which lead to enhanced anti‐biofilm activity.
format Online
Article
Text
id pubmed-9321984
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93219842022-07-30 Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms Ndukwe, Audrey R. N. Wiedbrauk, Sandra Boase, Nathan R. B. Fairfull‐Smith, Kathryn E. Chem Asian J Reviews Biofilms are part of the natural lifecycle of bacteria and are known to cause chronic infections that are difficult to treat. Most antibiotics are developed and tested against bacteria in the planktonic state and are ineffective against bacterial biofilms. The oxazolidinones, including the last resort drug linezolid, are one of the main classes of synthetic antibiotics progressed to clinical use in the last 50 years. They have a unique mechanism of action and only develop low levels of resistance in the clinical setting. With the aim of providing insight into strategies to design more potent antibiotic compounds with activity against bacterial biofilms, we review the biofilm activity of clinically approved oxazolidinones and report on structural modifications to oxazolidinones and their delivery systems which lead to enhanced anti‐biofilm activity. John Wiley and Sons Inc. 2022-04-13 2022-06-01 /pmc/articles/PMC9321984/ /pubmed/35352479 http://dx.doi.org/10.1002/asia.202200201 Text en © 2022 The Authors. Chemistry - An Asian Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Ndukwe, Audrey R. N.
Wiedbrauk, Sandra
Boase, Nathan R. B.
Fairfull‐Smith, Kathryn E.
Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title_full Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title_fullStr Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title_full_unstemmed Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title_short Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms
title_sort strategies to improve the potency of oxazolidinones towards bacterial biofilms
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321984/
https://www.ncbi.nlm.nih.gov/pubmed/35352479
http://dx.doi.org/10.1002/asia.202200201
work_keys_str_mv AT ndukweaudreyrn strategiestoimprovethepotencyofoxazolidinonestowardsbacterialbiofilms
AT wiedbrauksandra strategiestoimprovethepotencyofoxazolidinonestowardsbacterialbiofilms
AT boasenathanrb strategiestoimprovethepotencyofoxazolidinonestowardsbacterialbiofilms
AT fairfullsmithkathryne strategiestoimprovethepotencyofoxazolidinonestowardsbacterialbiofilms