Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes

There is a constant need for deuterium‐labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently s...

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Autores principales: Bourriquen, Florian, Rockstroh, Nils, Bartling, Stephan, Junge, Kathrin, Beller, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322005/
https://www.ncbi.nlm.nih.gov/pubmed/35484978
http://dx.doi.org/10.1002/anie.202202423
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author Bourriquen, Florian
Rockstroh, Nils
Bartling, Stephan
Junge, Kathrin
Beller, Matthias
author_facet Bourriquen, Florian
Rockstroh, Nils
Bartling, Stephan
Junge, Kathrin
Beller, Matthias
author_sort Bourriquen, Florian
collection PubMed
description There is a constant need for deuterium‐labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesised and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst has been fully characterised and successfully applied to the labelling of natural products as well as marketed drugs.
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spelling pubmed-93220052022-07-30 Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes Bourriquen, Florian Rockstroh, Nils Bartling, Stephan Junge, Kathrin Beller, Matthias Angew Chem Int Ed Engl Research Articles There is a constant need for deuterium‐labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesised and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst has been fully characterised and successfully applied to the labelling of natural products as well as marketed drugs. John Wiley and Sons Inc. 2022-05-12 2022-07-04 /pmc/articles/PMC9322005/ /pubmed/35484978 http://dx.doi.org/10.1002/anie.202202423 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Bourriquen, Florian
Rockstroh, Nils
Bartling, Stephan
Junge, Kathrin
Beller, Matthias
Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title_full Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title_fullStr Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title_full_unstemmed Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title_short Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero)Arenes
title_sort manganese‐catalysed deuterium labelling of anilines and electron‐rich (hetero)arenes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322005/
https://www.ncbi.nlm.nih.gov/pubmed/35484978
http://dx.doi.org/10.1002/anie.202202423
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