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Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as tran...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322055/ https://www.ncbi.nlm.nih.gov/pubmed/35890323 http://dx.doi.org/10.3390/pharmaceutics14071428 |
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author | Jailani, Afreen Kalimuthu, Shanthini Rajasekar, Vidhyashree Ghosh, Sumanta Collart-Dutilleul, Pierre-Yves Fatima, Naveen Koo, Hyun Solomon, Adline Princy Cuisinier, Frederic Neelakantan, Prasanna |
author_facet | Jailani, Afreen Kalimuthu, Shanthini Rajasekar, Vidhyashree Ghosh, Sumanta Collart-Dutilleul, Pierre-Yves Fatima, Naveen Koo, Hyun Solomon, Adline Princy Cuisinier, Frederic Neelakantan, Prasanna |
author_sort | Jailani, Afreen |
collection | PubMed |
description | Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as trans-cinnamaldehyde in thwarting biofilm assembly, and yet, the remarkable difficulty in delivering such hydrophobic bioactive molecules prevents further development. To address this critical challenge, we have developed an innovative platform composed of components with a proven track record of safety. We fabricated and thoroughly characterised porous silicon (pSi) microparticles to carry and deliver the natural phenyl propanoid trans-cinnamaldehyde (TC). We investigated its effects on preventing the development of cross-kingdom biofilms (Streptococcus mutans and Candida albicans), typical of dental caries found in children. The prepared pSi microparticles were roughly cubic in structure with 70–75% porosity, to which the TC (pSi-TC) was loaded with about 45% efficiency. The pSi-TC particles exhibited a controlled release of the cargo over a 14-day period. Notably, pSi-TC significantly inhibited biofilms, specifically downregulating the glucan synthesis pathways, leading to reduced adhesion to the substrate. Acid production, a vital virulent trait for caries development, was also hindered by pSi-TC. This pioneering study highlights the potential to develop the novel pSi-TC as a dental caries-preventive material. |
format | Online Article Text |
id | pubmed-9322055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93220552022-07-27 Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms Jailani, Afreen Kalimuthu, Shanthini Rajasekar, Vidhyashree Ghosh, Sumanta Collart-Dutilleul, Pierre-Yves Fatima, Naveen Koo, Hyun Solomon, Adline Princy Cuisinier, Frederic Neelakantan, Prasanna Pharmaceutics Article Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as trans-cinnamaldehyde in thwarting biofilm assembly, and yet, the remarkable difficulty in delivering such hydrophobic bioactive molecules prevents further development. To address this critical challenge, we have developed an innovative platform composed of components with a proven track record of safety. We fabricated and thoroughly characterised porous silicon (pSi) microparticles to carry and deliver the natural phenyl propanoid trans-cinnamaldehyde (TC). We investigated its effects on preventing the development of cross-kingdom biofilms (Streptococcus mutans and Candida albicans), typical of dental caries found in children. The prepared pSi microparticles were roughly cubic in structure with 70–75% porosity, to which the TC (pSi-TC) was loaded with about 45% efficiency. The pSi-TC particles exhibited a controlled release of the cargo over a 14-day period. Notably, pSi-TC significantly inhibited biofilms, specifically downregulating the glucan synthesis pathways, leading to reduced adhesion to the substrate. Acid production, a vital virulent trait for caries development, was also hindered by pSi-TC. This pioneering study highlights the potential to develop the novel pSi-TC as a dental caries-preventive material. MDPI 2022-07-07 /pmc/articles/PMC9322055/ /pubmed/35890323 http://dx.doi.org/10.3390/pharmaceutics14071428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jailani, Afreen Kalimuthu, Shanthini Rajasekar, Vidhyashree Ghosh, Sumanta Collart-Dutilleul, Pierre-Yves Fatima, Naveen Koo, Hyun Solomon, Adline Princy Cuisinier, Frederic Neelakantan, Prasanna Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title | Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title_full | Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title_fullStr | Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title_full_unstemmed | Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title_short | Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms |
title_sort | trans-cinnamaldehyde eluting porous silicon microparticles mitigate cariogenic biofilms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322055/ https://www.ncbi.nlm.nih.gov/pubmed/35890323 http://dx.doi.org/10.3390/pharmaceutics14071428 |
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