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Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms

Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as tran...

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Autores principales: Jailani, Afreen, Kalimuthu, Shanthini, Rajasekar, Vidhyashree, Ghosh, Sumanta, Collart-Dutilleul, Pierre-Yves, Fatima, Naveen, Koo, Hyun, Solomon, Adline Princy, Cuisinier, Frederic, Neelakantan, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322055/
https://www.ncbi.nlm.nih.gov/pubmed/35890323
http://dx.doi.org/10.3390/pharmaceutics14071428
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author Jailani, Afreen
Kalimuthu, Shanthini
Rajasekar, Vidhyashree
Ghosh, Sumanta
Collart-Dutilleul, Pierre-Yves
Fatima, Naveen
Koo, Hyun
Solomon, Adline Princy
Cuisinier, Frederic
Neelakantan, Prasanna
author_facet Jailani, Afreen
Kalimuthu, Shanthini
Rajasekar, Vidhyashree
Ghosh, Sumanta
Collart-Dutilleul, Pierre-Yves
Fatima, Naveen
Koo, Hyun
Solomon, Adline Princy
Cuisinier, Frederic
Neelakantan, Prasanna
author_sort Jailani, Afreen
collection PubMed
description Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as trans-cinnamaldehyde in thwarting biofilm assembly, and yet, the remarkable difficulty in delivering such hydrophobic bioactive molecules prevents further development. To address this critical challenge, we have developed an innovative platform composed of components with a proven track record of safety. We fabricated and thoroughly characterised porous silicon (pSi) microparticles to carry and deliver the natural phenyl propanoid trans-cinnamaldehyde (TC). We investigated its effects on preventing the development of cross-kingdom biofilms (Streptococcus mutans and Candida albicans), typical of dental caries found in children. The prepared pSi microparticles were roughly cubic in structure with 70–75% porosity, to which the TC (pSi-TC) was loaded with about 45% efficiency. The pSi-TC particles exhibited a controlled release of the cargo over a 14-day period. Notably, pSi-TC significantly inhibited biofilms, specifically downregulating the glucan synthesis pathways, leading to reduced adhesion to the substrate. Acid production, a vital virulent trait for caries development, was also hindered by pSi-TC. This pioneering study highlights the potential to develop the novel pSi-TC as a dental caries-preventive material.
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spelling pubmed-93220552022-07-27 Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms Jailani, Afreen Kalimuthu, Shanthini Rajasekar, Vidhyashree Ghosh, Sumanta Collart-Dutilleul, Pierre-Yves Fatima, Naveen Koo, Hyun Solomon, Adline Princy Cuisinier, Frederic Neelakantan, Prasanna Pharmaceutics Article Dental caries, a preventable disease, is caused by highly-adherent, acid-producing biofilms composed of bacteria and yeasts. Current caries-preventive approaches are ineffective in controlling biofilm development. Recent studies demonstrate definite advantages in using natural compounds such as trans-cinnamaldehyde in thwarting biofilm assembly, and yet, the remarkable difficulty in delivering such hydrophobic bioactive molecules prevents further development. To address this critical challenge, we have developed an innovative platform composed of components with a proven track record of safety. We fabricated and thoroughly characterised porous silicon (pSi) microparticles to carry and deliver the natural phenyl propanoid trans-cinnamaldehyde (TC). We investigated its effects on preventing the development of cross-kingdom biofilms (Streptococcus mutans and Candida albicans), typical of dental caries found in children. The prepared pSi microparticles were roughly cubic in structure with 70–75% porosity, to which the TC (pSi-TC) was loaded with about 45% efficiency. The pSi-TC particles exhibited a controlled release of the cargo over a 14-day period. Notably, pSi-TC significantly inhibited biofilms, specifically downregulating the glucan synthesis pathways, leading to reduced adhesion to the substrate. Acid production, a vital virulent trait for caries development, was also hindered by pSi-TC. This pioneering study highlights the potential to develop the novel pSi-TC as a dental caries-preventive material. MDPI 2022-07-07 /pmc/articles/PMC9322055/ /pubmed/35890323 http://dx.doi.org/10.3390/pharmaceutics14071428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jailani, Afreen
Kalimuthu, Shanthini
Rajasekar, Vidhyashree
Ghosh, Sumanta
Collart-Dutilleul, Pierre-Yves
Fatima, Naveen
Koo, Hyun
Solomon, Adline Princy
Cuisinier, Frederic
Neelakantan, Prasanna
Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title_full Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title_fullStr Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title_full_unstemmed Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title_short Trans-Cinnamaldehyde Eluting Porous Silicon Microparticles Mitigate Cariogenic Biofilms
title_sort trans-cinnamaldehyde eluting porous silicon microparticles mitigate cariogenic biofilms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322055/
https://www.ncbi.nlm.nih.gov/pubmed/35890323
http://dx.doi.org/10.3390/pharmaceutics14071428
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