Cargando…

Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial

Background: Extracts of medicinal plant like lemongrass offer a new choice for optional antimicrobial therapy against various oral microorganisms. The objective of this study was to assess, verify, and compare the antimicrobial effectiveness of locally administered 2% lemongrass gel and 10% doxycycl...

Descripción completa

Detalles Bibliográficos
Autores principales: Mittal, Pooja, Gokhale, Shankar T., Manjunath, Shiva, Al-Qahtani, Saad M., Magbol, Mohammad Al., Nagate, Raghavendra Reddy, Tikare, Shreyas, Chaturvedi, Saurabh, Agarwal, Ashish, Venkataram, Vatsala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322070/
https://www.ncbi.nlm.nih.gov/pubmed/35890542
http://dx.doi.org/10.3390/polym14142766
_version_ 1784756206704787456
author Mittal, Pooja
Gokhale, Shankar T.
Manjunath, Shiva
Al-Qahtani, Saad M.
Magbol, Mohammad Al.
Nagate, Raghavendra Reddy
Tikare, Shreyas
Chaturvedi, Saurabh
Agarwal, Ashish
Venkataram, Vatsala
author_facet Mittal, Pooja
Gokhale, Shankar T.
Manjunath, Shiva
Al-Qahtani, Saad M.
Magbol, Mohammad Al.
Nagate, Raghavendra Reddy
Tikare, Shreyas
Chaturvedi, Saurabh
Agarwal, Ashish
Venkataram, Vatsala
author_sort Mittal, Pooja
collection PubMed
description Background: Extracts of medicinal plant like lemongrass offer a new choice for optional antimicrobial therapy against various oral microorganisms. The objective of this study was to assess, verify, and compare the antimicrobial effectiveness of locally administered 2% lemongrass gel and 10% doxycycline hyclate gel as an adjunct to scaling and root planing (SRP) in treating chronic periodontitis. Method: This is a double-blind parallel arm randomized controlled study. Forty subjects were randomly divided into Group A and B for 2% lemongrass gel and 10% doxycycline hyclate gel, respectively. The clinical assessments of Gingival Index (GI), Plaque Index (PI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) together with microbial colony counts for Porphyromonas gingivalis, Actinomyces naeslundii, and Prevotella intermedia were done at baseline, 1st month, and 3rd month follow-ups. Results: The results showed there was a significant reduction in the mean scores of GI, PPD, and CAL clinical indices from baseline to the 1st and 3rd month follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05). Similarly, there was significant reduction in mean CFU scores for all periodontal pathogens from baseline to 1st and 3rd month follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05). Conclusions: It could be concluded that the local delivery of 2% lemongrass gel as an adjunct to scaling and root planing is effective and comparable to 10% doxycycline gel in the treatment of chronic periodontitis.
format Online
Article
Text
id pubmed-9322070
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93220702022-07-27 Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial Mittal, Pooja Gokhale, Shankar T. Manjunath, Shiva Al-Qahtani, Saad M. Magbol, Mohammad Al. Nagate, Raghavendra Reddy Tikare, Shreyas Chaturvedi, Saurabh Agarwal, Ashish Venkataram, Vatsala Polymers (Basel) Article Background: Extracts of medicinal plant like lemongrass offer a new choice for optional antimicrobial therapy against various oral microorganisms. The objective of this study was to assess, verify, and compare the antimicrobial effectiveness of locally administered 2% lemongrass gel and 10% doxycycline hyclate gel as an adjunct to scaling and root planing (SRP) in treating chronic periodontitis. Method: This is a double-blind parallel arm randomized controlled study. Forty subjects were randomly divided into Group A and B for 2% lemongrass gel and 10% doxycycline hyclate gel, respectively. The clinical assessments of Gingival Index (GI), Plaque Index (PI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) together with microbial colony counts for Porphyromonas gingivalis, Actinomyces naeslundii, and Prevotella intermedia were done at baseline, 1st month, and 3rd month follow-ups. Results: The results showed there was a significant reduction in the mean scores of GI, PPD, and CAL clinical indices from baseline to the 1st and 3rd month follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05). Similarly, there was significant reduction in mean CFU scores for all periodontal pathogens from baseline to 1st and 3rd month follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05). Conclusions: It could be concluded that the local delivery of 2% lemongrass gel as an adjunct to scaling and root planing is effective and comparable to 10% doxycycline gel in the treatment of chronic periodontitis. MDPI 2022-07-06 /pmc/articles/PMC9322070/ /pubmed/35890542 http://dx.doi.org/10.3390/polym14142766 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mittal, Pooja
Gokhale, Shankar T.
Manjunath, Shiva
Al-Qahtani, Saad M.
Magbol, Mohammad Al.
Nagate, Raghavendra Reddy
Tikare, Shreyas
Chaturvedi, Saurabh
Agarwal, Ashish
Venkataram, Vatsala
Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title_full Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title_fullStr Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title_full_unstemmed Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title_short Comparative Evaluation of Locally Administered 2% Gel Fabricated from Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled Trial
title_sort comparative evaluation of locally administered 2% gel fabricated from lemongrass polymer and 10% doxycycline hyclate gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis—a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322070/
https://www.ncbi.nlm.nih.gov/pubmed/35890542
http://dx.doi.org/10.3390/polym14142766
work_keys_str_mv AT mittalpooja comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT gokhaleshankart comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT manjunathshiva comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT alqahtanisaadm comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT magbolmohammadal comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT nagateraghavendrareddy comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT tikareshreyas comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT chaturvedisaurabh comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT agarwalashish comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial
AT venkataramvatsala comparativeevaluationoflocallyadministered2gelfabricatedfromlemongrasspolymerand10doxycyclinehyclategelasanadjuncttoscalingandrootplaninginthetreatmentofchronicperiodontitisarandomizedcontrolledtrial