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Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder

In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). We obtained resting-state functional magnetic resonance images of yo...

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Autores principales: Hong, Soon-Beom, Hwang, Seungsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322108/
https://www.ncbi.nlm.nih.gov/pubmed/35903637
http://dx.doi.org/10.3389/fpsyt.2022.918700
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author Hong, Soon-Beom
Hwang, Seungsik
author_facet Hong, Soon-Beom
Hwang, Seungsik
author_sort Hong, Soon-Beom
collection PubMed
description In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). We obtained resting-state functional magnetic resonance images of youth with ADHD and typically developing counterparts from the publicly available ADHD-200 database. We used data from Peking University (232 scans) and New York University (172 scans); the scan repetition time was 2 s for both data collection sites. We applied generalized estimating equations to estimate the variability of the averaged blood-oxygen-level-dependent (BOLD) time series extracted from the DMN at rest. We performed network-based statistics to determine the association between the observed differences in BOLD signal variability and altered functional connectivity. We analyzed data from 105 youth with ADHD (age: mean 12.17, standard deviation 2.31, median 12.25; 15.2% female, 84.8% male) and 140 typically developing youth (age: mean 11.99, standard deviation 2.28, median 11.85; 47.1% female, 52.9% male), who aged 7–17 years. The imaging data were cross-sectionally collected for each participant at one time point. We observed a greater number of significant BOLD signal changes and higher-order polynomial significant associations in youth with ADHD. Moreover, there were significant between-group differences in BOLD signal change after the first 140 s, which coincided with decreased resting-state functional connectivity within the DMN in youth with ADHD. Increased variability of neural signaling was intermittently observed in the brains of youth with ADHD at rest, thereby indicating their default mode state was more unstable than that of typically developing youth.
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spelling pubmed-93221082022-07-27 Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder Hong, Soon-Beom Hwang, Seungsik Front Psychiatry Psychiatry In this study, we sought to determine the nature of the abnormality in resting-state default mode network (DMN) activation and explore its correlation with functional connectivity in attention-deficit/hyperactivity disorder (ADHD). We obtained resting-state functional magnetic resonance images of youth with ADHD and typically developing counterparts from the publicly available ADHD-200 database. We used data from Peking University (232 scans) and New York University (172 scans); the scan repetition time was 2 s for both data collection sites. We applied generalized estimating equations to estimate the variability of the averaged blood-oxygen-level-dependent (BOLD) time series extracted from the DMN at rest. We performed network-based statistics to determine the association between the observed differences in BOLD signal variability and altered functional connectivity. We analyzed data from 105 youth with ADHD (age: mean 12.17, standard deviation 2.31, median 12.25; 15.2% female, 84.8% male) and 140 typically developing youth (age: mean 11.99, standard deviation 2.28, median 11.85; 47.1% female, 52.9% male), who aged 7–17 years. The imaging data were cross-sectionally collected for each participant at one time point. We observed a greater number of significant BOLD signal changes and higher-order polynomial significant associations in youth with ADHD. Moreover, there were significant between-group differences in BOLD signal change after the first 140 s, which coincided with decreased resting-state functional connectivity within the DMN in youth with ADHD. Increased variability of neural signaling was intermittently observed in the brains of youth with ADHD at rest, thereby indicating their default mode state was more unstable than that of typically developing youth. Frontiers Media S.A. 2022-07-12 /pmc/articles/PMC9322108/ /pubmed/35903637 http://dx.doi.org/10.3389/fpsyt.2022.918700 Text en Copyright © 2022 Hong and Hwang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Hong, Soon-Beom
Hwang, Seungsik
Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title_full Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title_fullStr Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title_full_unstemmed Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title_short Resting-State Brain Variability in Youth With Attention-Deficit/Hyperactivity Disorder
title_sort resting-state brain variability in youth with attention-deficit/hyperactivity disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322108/
https://www.ncbi.nlm.nih.gov/pubmed/35903637
http://dx.doi.org/10.3389/fpsyt.2022.918700
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