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Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors

A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in silico, and those with the 2-aminophenylsulfi...

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Detalles Bibliográficos
Autores principales:	Díaz, Iván, Salido, Sofia, Nogueras, Manuel, Cobo, Justo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322123/ https://www.ncbi.nlm.nih.gov/pubmed/35890090 http://dx.doi.org/10.3390/ph15070792

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