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SIRT1 activity orchestrates ECM expression during hESC‐chondrogenic differentiation

Epigenetic modification is a key driver of differentiation, and the deacetylase Sirtuin1 (SIRT1) is an established regulator of cell function, ageing, and articular cartilage homeostasis. Here we investigate the role of SIRT1 during development of chondrocytes by using human embryonic stem cells (hE...

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Detalles Bibliográficos
Autores principales:	Smith, Christopher A., Humphreys, Paul A., Bates, Nicola, Naven, Mark A., Cain, Stuart A., Dvir‐Ginzberg, Mona, Kimber, Susan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322318/ https://www.ncbi.nlm.nih.gov/pubmed/35416346 http://dx.doi.org/10.1096/fj.202200169R

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