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A Phase 1 study of ADI‐PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1‐negative metastatic uveal melanoma

Metastatic uveal melanoma (UM) is a devastating disease with few treatment options. We evaluated the safety, tolerability and preliminary activity of arginine depletion using pegylated arginine deiminase (ADI‐PEG20; pegargiminase) combined with pemetrexed (Pem) and cisplatin (Cis) chemotherapy in a...

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Detalles Bibliográficos
Autores principales:	Chan, Pui Ying, Phillips, Melissa M., Ellis, Stephen, Johnston, Amanda, Feng, Xiaoxing, Arora, Amit, Hay, Gordon, Cohen, Victoria M. L., Sagoo, Mandeep S., Bomalaski, John S., Sheaff, Michael T., Szlosarek, Peter W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322321/ https://www.ncbi.nlm.nih.gov/pubmed/35466524 http://dx.doi.org/10.1111/pcmr.13042

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