Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.

A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the...

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Detalles Bibliográficos
Autores principales: West, Korbin H. J., Gahan, Curran G., Kierski, Patricia R., Calderon, Diego F., Zhao, Ke, Czuprynski, Charles J., McAnulty, Jonathan F., Lynn, David M., Blackwell, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322450/
https://www.ncbi.nlm.nih.gov/pubmed/35334139
http://dx.doi.org/10.1002/anie.202201798
Descripción
Sumario:A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.[Image: see text]

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