Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.

A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the...

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Autores principales: West, Korbin H. J., Gahan, Curran G., Kierski, Patricia R., Calderon, Diego F., Zhao, Ke, Czuprynski, Charles J., McAnulty, Jonathan F., Lynn, David M., Blackwell, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322450/
https://www.ncbi.nlm.nih.gov/pubmed/35334139
http://dx.doi.org/10.1002/anie.202201798
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author West, Korbin H. J.
Gahan, Curran G.
Kierski, Patricia R.
Calderon, Diego F.
Zhao, Ke
Czuprynski, Charles J.
McAnulty, Jonathan F.
Lynn, David M.
Blackwell, Helen E.
author_facet West, Korbin H. J.
Gahan, Curran G.
Kierski, Patricia R.
Calderon, Diego F.
Zhao, Ke
Czuprynski, Charles J.
McAnulty, Jonathan F.
Lynn, David M.
Blackwell, Helen E.
author_sort West, Korbin H. J.
collection PubMed
description A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.[Image: see text]
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spelling pubmed-93224502022-07-30 Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo. West, Korbin H. J. Gahan, Curran G. Kierski, Patricia R. Calderon, Diego F. Zhao, Ke Czuprynski, Charles J. McAnulty, Jonathan F. Lynn, David M. Blackwell, Helen E. Angew Chem Int Ed Engl Research Articles A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.[Image: see text] John Wiley and Sons Inc. 2022-04-12 2022-06-13 /pmc/articles/PMC9322450/ /pubmed/35334139 http://dx.doi.org/10.1002/anie.202201798 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
West, Korbin H. J.
Gahan, Curran G.
Kierski, Patricia R.
Calderon, Diego F.
Zhao, Ke
Czuprynski, Charles J.
McAnulty, Jonathan F.
Lynn, David M.
Blackwell, Helen E.
Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title_full Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title_fullStr Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title_full_unstemmed Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title_short Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.
title_sort sustained release of a synthetic autoinducing peptide mimetic blocks bacterial communication and virulence in vivo.
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322450/
https://www.ncbi.nlm.nih.gov/pubmed/35334139
http://dx.doi.org/10.1002/anie.202201798
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