CD163+ M2 Macrophages Promote Fibrosis in IgG4‐Related Disease Via Toll‐like Receptor 7/Interleukin‐1 Receptor–Associated Kinase 4/NF‐κB Signaling

OBJECTIVE: IgG4‐related disease (IgG4‐RD) is a fibro‐inflammatory condition that can affect multiple organs. We previously demonstrated that TLR7‐transgenic C57BL/6 mice showed elevated serum IgG1 levels and inflammation with fibrosis in the salivary glands (SGs), lungs, and pancreas. Moreover, we o...

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Detalles Bibliográficos
Autores principales: Chinju, Akira, Moriyama, Masafumi, Kakizoe‐Ishiguro, Noriko, Chen, Hu, Miyahara, Yuka, Haque, A. S. M. Rafiul, Furusho, Katsuhiro, Sakamoto, Mizuki, Kai, Kazuki, Kibe, Kotono, Hatakeyama‐Furukawa, Sachiko, Ito‐Ohta, Miho, Maehara, Takashi, Nakamura, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2022
Materias:
IgG4‐Related Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322461/
https://www.ncbi.nlm.nih.gov/pubmed/34907668
http://dx.doi.org/10.1002/art.42043

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