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Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review
Currently, medication for benign prostate hyperplasia (BPH) and prostate cancer (PCa) are mainly based on modulating the hormone and nervous systems. However, side effects often affect patients, and might decrease their commitment to continuing the medication and lower their quality of life. Some st...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322491/ https://www.ncbi.nlm.nih.gov/pubmed/35888117 http://dx.doi.org/10.3390/life12071029 |
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author | Yang, Che-Hsueh Ou, Yen-Chuan Lin, Chi-Chien Lin, Yi-Sheng Tung, Min-Che Yu, Chia-Cheng Lin, Jen-Tai Wen, Chen-Yueh |
author_facet | Yang, Che-Hsueh Ou, Yen-Chuan Lin, Chi-Chien Lin, Yi-Sheng Tung, Min-Che Yu, Chia-Cheng Lin, Jen-Tai Wen, Chen-Yueh |
author_sort | Yang, Che-Hsueh |
collection | PubMed |
description | Currently, medication for benign prostate hyperplasia (BPH) and prostate cancer (PCa) are mainly based on modulating the hormone and nervous systems. However, side effects often affect patients, and might decrease their commitment to continuing the medication and lower their quality of life. Some studies have indicated that chronic inflammation might be the cause of BPH and PCa. Based on this hypothesis, the effect of phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, has been researched since 2010. Results from animal and in-vitro studies, obtained from databases, also indicate that the use of phloretin in treating BPH and PCa is promising. Due to its effect on inflammatory cytokines, apoptosis or anti-apoptosis, reactive oxygen species, anti-oxidant enzymes and oxidative stress, phloretin is worthy of further study in human clinical trials regarding safety and effective dosages. |
format | Online Article Text |
id | pubmed-9322491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93224912022-07-27 Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review Yang, Che-Hsueh Ou, Yen-Chuan Lin, Chi-Chien Lin, Yi-Sheng Tung, Min-Che Yu, Chia-Cheng Lin, Jen-Tai Wen, Chen-Yueh Life (Basel) Review Currently, medication for benign prostate hyperplasia (BPH) and prostate cancer (PCa) are mainly based on modulating the hormone and nervous systems. However, side effects often affect patients, and might decrease their commitment to continuing the medication and lower their quality of life. Some studies have indicated that chronic inflammation might be the cause of BPH and PCa. Based on this hypothesis, the effect of phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, has been researched since 2010. Results from animal and in-vitro studies, obtained from databases, also indicate that the use of phloretin in treating BPH and PCa is promising. Due to its effect on inflammatory cytokines, apoptosis or anti-apoptosis, reactive oxygen species, anti-oxidant enzymes and oxidative stress, phloretin is worthy of further study in human clinical trials regarding safety and effective dosages. MDPI 2022-07-11 /pmc/articles/PMC9322491/ /pubmed/35888117 http://dx.doi.org/10.3390/life12071029 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Che-Hsueh Ou, Yen-Chuan Lin, Chi-Chien Lin, Yi-Sheng Tung, Min-Che Yu, Chia-Cheng Lin, Jen-Tai Wen, Chen-Yueh Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title_full | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title_fullStr | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title_full_unstemmed | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title_short | Phloretin in Benign Prostate Hyperplasia and Prostate Cancer: A Contemporary Systematic Review |
title_sort | phloretin in benign prostate hyperplasia and prostate cancer: a contemporary systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322491/ https://www.ncbi.nlm.nih.gov/pubmed/35888117 http://dx.doi.org/10.3390/life12071029 |
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