A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling

The antihypertensive felodipine is a calcium channel blocker of the dihydropyridine type, and its pharmacodynamic effect directly correlates with its plasma concentration. As a sensitive substrate of cytochrome P450 (CYP) 3A4 with high first-pass metabolism, felodipine shows low oral bioavailability...

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Detalles Bibliográficos
Autores principales: Fuhr, Laura Maria, Marok, Fatima Zahra, Mees, Maximilian, Mahfoud, Felix, Selzer, Dominik, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322514/
https://www.ncbi.nlm.nih.gov/pubmed/35890369
http://dx.doi.org/10.3390/pharmaceutics14071474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322514/
https://www.ncbi.nlm.nih.gov/pubmed/35890369
http://dx.doi.org/10.3390/pharmaceutics14071474

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