Cargando…

IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport

The treatment of neurological disorders with large-molecule biotherapeutics requires that the therapeutic drug be transported across the blood–brain barrier (BBB). However, recombinant biotherapeutics, such as neurotrophins, enzymes, decoy receptors, and monoclonal antibodies (MAb), do not cross the...

Descripción completa

Detalles Bibliográficos
Autor principal:	Boado, Ruben J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322584/ https://www.ncbi.nlm.nih.gov/pubmed/35890374 http://dx.doi.org/10.3390/pharmaceutics14071476

Ejemplares similares

Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery
por: Boado, Ruben J., et al.
Publicado: (2019)

Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery
por: Pardridge, William M., et al.
Publicado: (2009)

Effects of neuromyelitis optica–IgG at the blood–brain barrier in vitro
por: Takeshita, Yukio, et al.
Publicado: (2016)

Receptor-mediated transport of IgG
por: Rodewald, R., et al.
Publicado: (1984)

Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells
por: Boado, Ruben J., et al.
Publicado: (2014)

The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier
por: Boado, Ruben J., et al.
Publicado: (2011)

Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions
por: Petry, Janina, et al.
Publicado: (2020)

Specificity of fc receptors for IgG2a, IgG1/IgG2b, and IgE on rat macrophages
Publicado: (1981)

Subclasses of allergen-specific IgG: Serum IgG2 and IgG3 levels are not predicted by IgG1/IgG4 levels
por: MacGlashan, Donald, et al.
Publicado: (2021)

Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability
por: Cobo-Calvo, Alvaro, et al.
Publicado: (2020)

Treatment of Parkinson’s disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport
por: Pardridge, William M.
Publicado: (2023)

Transport of neutral IgG2 versus anionic IgG4 in PD: implications on the electrokinetic model
por: Pletinck, Anneleen, et al.
Publicado: (2018)

IgG Charge: Practical and Biological Implications
por: Yang, Danlin, et al.
Publicado: (2019)

Prevention of Dominant IgG Adsorption on Nanocarriers in IgG‐Enriched Blood Plasma by Clusterin Precoating
por: Prozeller, Domenik, et al.
Publicado: (2019)

The antiinflammatory activity of IgG: the intravenous IgG paradox
por: Nimmerjahn, Falk, et al.
Publicado: (2007)

The Blood of the HIV-Infected Patients Contains κ-IgG, λ-IgG, and Bispecific κλ-IgG, Which Possess DNase and Amylolytic Activity
por: Timofeeva, Anna, et al.
Publicado: (2022)

Serum IgG4 levels outperform IgG4/IgG RNA ratio in differential diagnosis of IgG4-related disease
por: Schulte, Lucas A., et al.
Publicado: (2020)

Leptomeningeal and Intraparenchymal Blood Barrier Disruption in a MOG-IgG-Positive Patient
por: Mohseni, Seyed Hamidreza, et al.
Publicado: (2018)

Selective localization of IgG from cerebrospinal fluid to brain parenchyma
por: Mørch, Marlene Thorsen, et al.
Publicado: (2018)

Association of dengue infection with anti-alpha-gal antibodies, IgM, IgG, IgG1, and IgG2
por: Olajiga, Olayinka M., et al.
Publicado: (2022)

Definition of IgG Subclass-Specific Glycopatterns in Idiopathic Membranous Nephropathy: Aberrant IgG Glycoforms in Blood
por: Chinello, Clizia, et al.
Publicado: (2022)

Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme
por: Hahn, Andreas, et al.
Publicado: (2022)

The Expression of IgG and IgG4 in Orbital MALT Lymphoma: The Similarities and Differences of IgG4-Related Diseases
por: Li, Kai-Ming, et al.
Publicado: (2020)

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles
por: Thomsen, Maj Schneider, et al.
Publicado: (2022)

Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis
Publicado: (1986)

IgM, IgA, IgG1 and IgG2 specific responses in blood and gut secretion of calves fed soyabean products
por: Dréau, D., et al.
Publicado: (1995)

Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain
por: Saadoun, Samira, et al.
Publicado: (2014)

Lymphocyte membrane IgG and secreted IgG are structurally and allotypically distinct
Publicado: (1980)

Factors associated with IgG levels in adults with IgG subclass deficiency
por: Barton, James C., et al.
Publicado: (2021)

IgG-single-chain TRAIL fusion proteins for tumour therapy
por: Siegemund, Martin, et al.
Publicado: (2018)

Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease
por: Ueki, Kenji, et al.
Publicado: (2015)

Clinical significance of the detection of serum IgG4 and IgG4/IgG ratio in patients with thyroid-associated ophthalmopathy
por: Zhao, JianGuo, et al.
Publicado: (2023)

G Protein-Coupled Receptors in the Mammalian Blood-Brain Barrier
por: Pluimer, Brock R., et al.
Publicado: (2020)

C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro
por: Temming, A. Robin, et al.
Publicado: (2021)

Modulation of the Blood–Brain Barrier for Drug Delivery to Brain
por: Han, Liang
Publicado: (2021)

Mouse IgG2c Fc loop residues promote greater receptor-binding affinity than mouse IgG2b or human IgG1
por: Falconer, Daniel J., et al.
Publicado: (2018)

Clinical Evaluation of Antiphospholipase A2 Receptor IgG4 level and Its IgG4-to-IgG Ratio Based on Quantitative Immunoassays in Idiopathic Membranous Nephropathy
por: Zhang, Yi, et al.
Publicado: (2022)

IgG4/IgG RNA ratio does not accurately discriminate IgG4-related disease from pancreatobiliary cancer
por: de Vries, Elsemieke, et al.
Publicado: (2020)

Serologic Tests of IgG and IgM Antibodies and IgG Avidity for Diagnosis of Ocular Toxoplasmosis
por: Rahimi-Esboei, Bahman, et al.
Publicado: (2018)

PPD-specific IgG and IgG subclasses in the sera of pulmonary tuberculosis patients.
por: Hwang, P. H., et al.
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_nvoukdogg47f09tmsbsc237h3j