Cargando…

Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation

Objective: To use deep learning to predict the probability of triangular fibrocartilage complex (TFCC) injury in patients’ MRI scans. Methods: We retrospectively studied medical records over 11 years and 2 months (1 January 2009–29 February 2019), collecting 332 contrast-enhanced hand MRI scans show...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Kun-Yi, Li, Yuan-Ta, Han, Juin-Yi, Wu, Chia-Chun, Chu, Chi-Min, Peng, Shao-Yu, Yeh, Tsu-Te
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322609/
https://www.ncbi.nlm.nih.gov/pubmed/35887524
http://dx.doi.org/10.3390/jpm12071029
_version_ 1784756347012644864
author Lin, Kun-Yi
Li, Yuan-Ta
Han, Juin-Yi
Wu, Chia-Chun
Chu, Chi-Min
Peng, Shao-Yu
Yeh, Tsu-Te
author_facet Lin, Kun-Yi
Li, Yuan-Ta
Han, Juin-Yi
Wu, Chia-Chun
Chu, Chi-Min
Peng, Shao-Yu
Yeh, Tsu-Te
author_sort Lin, Kun-Yi
collection PubMed
description Objective: To use deep learning to predict the probability of triangular fibrocartilage complex (TFCC) injury in patients’ MRI scans. Methods: We retrospectively studied medical records over 11 years and 2 months (1 January 2009–29 February 2019), collecting 332 contrast-enhanced hand MRI scans showing TFCC injury (143 scans) or not (189 scans) from a general hospital. We employed two convolutional neural networks with the MRNet (Algorithm 1) and ResNet50 (Algorithm 2) framework for deep learning. Explainable artificial intelligence was used for heatmap analysis. We tested deep learning using an external dataset containing the MRI scans of 12 patients with TFCC injuries and 38 healthy subjects. Results: In the internal dataset, Algorithm 1 had an AUC of 0.809 (95% confidence interval—CI: 0.670–0.947) for TFCC injury detection as well as an accuracy, sensitivity, and specificity of 75.6% (95% CI: 0.613–0.858), 66.7% (95% CI: 0.438–0.837), and 81.5% (95% CI: 0.633–0.918), respectively, and an F1 score of 0.686. Algorithm 2 had an AUC of 0.871 (95% CI: 0.747–0.995) for TFCC injury detection and an accuracy, sensitivity, and specificity of 90.7% (95% CI: 0.787–0.962), 88.2% (95% CI: 0.664–0.966), and 92.3% (95% CI: 0.763–0.978), respectively, and an F1 score of 0.882. The accuracy, sensitivity, and specificity for radiologist 1 were 88.9, 94.4 and 85.2%, respectively, and for radiologist 2, they were 71.1, 100 and 51.9%, respectively. Conclusions: A modified MRNet framework enables the detection of TFCC injury and guides accurate diagnosis.
format Online
Article
Text
id pubmed-9322609
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93226092022-07-27 Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation Lin, Kun-Yi Li, Yuan-Ta Han, Juin-Yi Wu, Chia-Chun Chu, Chi-Min Peng, Shao-Yu Yeh, Tsu-Te J Pers Med Article Objective: To use deep learning to predict the probability of triangular fibrocartilage complex (TFCC) injury in patients’ MRI scans. Methods: We retrospectively studied medical records over 11 years and 2 months (1 January 2009–29 February 2019), collecting 332 contrast-enhanced hand MRI scans showing TFCC injury (143 scans) or not (189 scans) from a general hospital. We employed two convolutional neural networks with the MRNet (Algorithm 1) and ResNet50 (Algorithm 2) framework for deep learning. Explainable artificial intelligence was used for heatmap analysis. We tested deep learning using an external dataset containing the MRI scans of 12 patients with TFCC injuries and 38 healthy subjects. Results: In the internal dataset, Algorithm 1 had an AUC of 0.809 (95% confidence interval—CI: 0.670–0.947) for TFCC injury detection as well as an accuracy, sensitivity, and specificity of 75.6% (95% CI: 0.613–0.858), 66.7% (95% CI: 0.438–0.837), and 81.5% (95% CI: 0.633–0.918), respectively, and an F1 score of 0.686. Algorithm 2 had an AUC of 0.871 (95% CI: 0.747–0.995) for TFCC injury detection and an accuracy, sensitivity, and specificity of 90.7% (95% CI: 0.787–0.962), 88.2% (95% CI: 0.664–0.966), and 92.3% (95% CI: 0.763–0.978), respectively, and an F1 score of 0.882. The accuracy, sensitivity, and specificity for radiologist 1 were 88.9, 94.4 and 85.2%, respectively, and for radiologist 2, they were 71.1, 100 and 51.9%, respectively. Conclusions: A modified MRNet framework enables the detection of TFCC injury and guides accurate diagnosis. MDPI 2022-06-23 /pmc/articles/PMC9322609/ /pubmed/35887524 http://dx.doi.org/10.3390/jpm12071029 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Kun-Yi
Li, Yuan-Ta
Han, Juin-Yi
Wu, Chia-Chun
Chu, Chi-Min
Peng, Shao-Yu
Yeh, Tsu-Te
Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title_full Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title_fullStr Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title_full_unstemmed Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title_short Deep Learning to Detect Triangular Fibrocartilage Complex Injury in Wrist MRI: Retrospective Study with Internal and External Validation
title_sort deep learning to detect triangular fibrocartilage complex injury in wrist mri: retrospective study with internal and external validation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322609/
https://www.ncbi.nlm.nih.gov/pubmed/35887524
http://dx.doi.org/10.3390/jpm12071029
work_keys_str_mv AT linkunyi deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT liyuanta deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT hanjuinyi deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT wuchiachun deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT chuchimin deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT pengshaoyu deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation
AT yehtsute deeplearningtodetecttriangularfibrocartilagecomplexinjuryinwristmriretrospectivestudywithinternalandexternalvalidation