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Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata

In this study, we have specifically blocked a key step of sphingolipid (SL) biosynthesis in Candida glabrata by disruption of the orthologs of ScIpt1 and ScSkn1. Based on their close homology with S. cerevisiae counterparts, the proteins are predicted to catalyze the addition of a phosphorylinositol...

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Detalles Bibliográficos
Autores principales:	Shahi, Garima, Kumar, Mohit, Khandelwal, Nitesh Kumar, Banerjee, Atanu, Sarkar, Parijat, Kumari, Sonam, Esquivel, Brooke D., Chauhan, Neeraj, Chattopadhyay, Amitabha, White, Theodore C., Gaur, Naseem A., Singh, Ashutosh, Prasad, Rajendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322651/ https://www.ncbi.nlm.nih.gov/pubmed/35887407 http://dx.doi.org/10.3390/jof8070651

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