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Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents

Identifying asthma comorbidities in children is fundamental for improving disease management. We aimed to investigate the frequency of allergy-related comorbidities in children and adolescents with asthma, and to identify associated risk factors and disease burden. Between September 2015 and Decembe...

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Autores principales: Fasola, Salvatore, Ferrante, Giuliana, Cilluffo, Giovanna, Malizia, Velia, Alfano, Pietro, Montalbano, Laura, Cuttitta, Giuseppina, La Grutta, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322654/
https://www.ncbi.nlm.nih.gov/pubmed/35883985
http://dx.doi.org/10.3390/children9071001
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author Fasola, Salvatore
Ferrante, Giuliana
Cilluffo, Giovanna
Malizia, Velia
Alfano, Pietro
Montalbano, Laura
Cuttitta, Giuseppina
La Grutta, Stefania
author_facet Fasola, Salvatore
Ferrante, Giuliana
Cilluffo, Giovanna
Malizia, Velia
Alfano, Pietro
Montalbano, Laura
Cuttitta, Giuseppina
La Grutta, Stefania
author_sort Fasola, Salvatore
collection PubMed
description Identifying asthma comorbidities in children is fundamental for improving disease management. We aimed to investigate the frequency of allergy-related comorbidities in children and adolescents with asthma, and to identify associated risk factors and disease burden. Between September 2015 and December 2018, 508 asthmatic patients (5–17 years) were consecutively enrolled. Parents answered a standardized questionnaire on the history of disease and risk factors. Comorbidities were classified based on the involvement of respiratory and/or extra-respiratory districts: asthma only (A, 13%), asthma with respiratory comorbidities (AR, 37%), asthma with extra-respiratory comorbidities (AER, 10%), and asthma with both respiratory and extra-respiratory comorbidities (ARER, 40%). Multinomial logistic regression showed that membership in the AR group was significantly associated with a maternal history of asthma (OR = 3.08, 95% CI: 1.23–7.72), breastfeeding ≥ three months (OR = 1.92, 1.06–3.46), early mold exposure (OR = 2.39, 1.12–5.11), and current environmental tobacco smoke exposure (OR = 2.06, 1.11–3.83). Membership in the AER group was significantly associated with the female gender (OR = 3.43, 1.54–7.68), breastfeeding ≥ three months (OR = 2.77, 1.23–6.22). ARER was significantly associated with all the aforementioned exposures. Patients with AR reported exacerbations in the last 12 months more frequently (p = 0.009). Several personal and environmental risk factors are associated with comorbidities in asthmatic children and adolescents, possibly worsening the disease burden.
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spelling pubmed-93226542022-07-27 Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents Fasola, Salvatore Ferrante, Giuliana Cilluffo, Giovanna Malizia, Velia Alfano, Pietro Montalbano, Laura Cuttitta, Giuseppina La Grutta, Stefania Children (Basel) Article Identifying asthma comorbidities in children is fundamental for improving disease management. We aimed to investigate the frequency of allergy-related comorbidities in children and adolescents with asthma, and to identify associated risk factors and disease burden. Between September 2015 and December 2018, 508 asthmatic patients (5–17 years) were consecutively enrolled. Parents answered a standardized questionnaire on the history of disease and risk factors. Comorbidities were classified based on the involvement of respiratory and/or extra-respiratory districts: asthma only (A, 13%), asthma with respiratory comorbidities (AR, 37%), asthma with extra-respiratory comorbidities (AER, 10%), and asthma with both respiratory and extra-respiratory comorbidities (ARER, 40%). Multinomial logistic regression showed that membership in the AR group was significantly associated with a maternal history of asthma (OR = 3.08, 95% CI: 1.23–7.72), breastfeeding ≥ three months (OR = 1.92, 1.06–3.46), early mold exposure (OR = 2.39, 1.12–5.11), and current environmental tobacco smoke exposure (OR = 2.06, 1.11–3.83). Membership in the AER group was significantly associated with the female gender (OR = 3.43, 1.54–7.68), breastfeeding ≥ three months (OR = 2.77, 1.23–6.22). ARER was significantly associated with all the aforementioned exposures. Patients with AR reported exacerbations in the last 12 months more frequently (p = 0.009). Several personal and environmental risk factors are associated with comorbidities in asthmatic children and adolescents, possibly worsening the disease burden. MDPI 2022-07-03 /pmc/articles/PMC9322654/ /pubmed/35883985 http://dx.doi.org/10.3390/children9071001 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fasola, Salvatore
Ferrante, Giuliana
Cilluffo, Giovanna
Malizia, Velia
Alfano, Pietro
Montalbano, Laura
Cuttitta, Giuseppina
La Grutta, Stefania
Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title_full Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title_fullStr Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title_full_unstemmed Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title_short Asthma Comorbidities: Frequency, Risk Factors, and Associated Burden in Children and Adolescents
title_sort asthma comorbidities: frequency, risk factors, and associated burden in children and adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322654/
https://www.ncbi.nlm.nih.gov/pubmed/35883985
http://dx.doi.org/10.3390/children9071001
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