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Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis

Radiation exposure early in life is associated with greater incidences of malignancy. Our goal was to quantify radiation exposure in shunt-treated hydrocephalus patients and study changes in the diagnostic modalities used. A single-center, retrospective analysis was performed, and 41 children treate...

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Autores principales: Schabl, Lukas, Küppers, Julia, Jhala, Tobias, Winicker, Hermann, Esslinger, Peter, Lehner, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322797/
https://www.ncbi.nlm.nih.gov/pubmed/35884046
http://dx.doi.org/10.3390/children9071062
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author Schabl, Lukas
Küppers, Julia
Jhala, Tobias
Winicker, Hermann
Esslinger, Peter
Lehner, Markus
author_facet Schabl, Lukas
Küppers, Julia
Jhala, Tobias
Winicker, Hermann
Esslinger, Peter
Lehner, Markus
author_sort Schabl, Lukas
collection PubMed
description Radiation exposure early in life is associated with greater incidences of malignancy. Our goal was to quantify radiation exposure in shunt-treated hydrocephalus patients and study changes in the diagnostic modalities used. A single-center, retrospective analysis was performed, and 41 children treated for hydrocephalus using an adjustable ventriculoperitoneal shunt were identified. Diagnostics associated with hydrocephalus and other comorbidities were analyzed and radiation exposure was calculated. During 330.09 total shunt years, patients were exposed to a mean hydrocephalus-associated radiation dose of 3.93 mSv (range: 0–24.38 mSv), which amounted to a mean rate of 0.49 mSv per shunt year, respectively. Radiation exposure was greatest after shunt insertion in the first year of life. A continuous change from CT scans to MRIs could be seen over the study period, such that patients who underwent shunt insertion after 2017 were not exposed to additional hydrocephalus-associated radiation during their first year of life. Nevertheless, our patients, and a few individuals especially, seemed to be at higher risk for radiation sequelae. Our results suggest that CT scans should be substituted with MRIs, which decrease overall radiation exposure and can lead to zero additional radiation exposure during the first year of life after shunt insertion.
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spelling pubmed-93227972022-07-27 Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis Schabl, Lukas Küppers, Julia Jhala, Tobias Winicker, Hermann Esslinger, Peter Lehner, Markus Children (Basel) Article Radiation exposure early in life is associated with greater incidences of malignancy. Our goal was to quantify radiation exposure in shunt-treated hydrocephalus patients and study changes in the diagnostic modalities used. A single-center, retrospective analysis was performed, and 41 children treated for hydrocephalus using an adjustable ventriculoperitoneal shunt were identified. Diagnostics associated with hydrocephalus and other comorbidities were analyzed and radiation exposure was calculated. During 330.09 total shunt years, patients were exposed to a mean hydrocephalus-associated radiation dose of 3.93 mSv (range: 0–24.38 mSv), which amounted to a mean rate of 0.49 mSv per shunt year, respectively. Radiation exposure was greatest after shunt insertion in the first year of life. A continuous change from CT scans to MRIs could be seen over the study period, such that patients who underwent shunt insertion after 2017 were not exposed to additional hydrocephalus-associated radiation during their first year of life. Nevertheless, our patients, and a few individuals especially, seemed to be at higher risk for radiation sequelae. Our results suggest that CT scans should be substituted with MRIs, which decrease overall radiation exposure and can lead to zero additional radiation exposure during the first year of life after shunt insertion. MDPI 2022-07-16 /pmc/articles/PMC9322797/ /pubmed/35884046 http://dx.doi.org/10.3390/children9071062 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schabl, Lukas
Küppers, Julia
Jhala, Tobias
Winicker, Hermann
Esslinger, Peter
Lehner, Markus
Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title_full Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title_fullStr Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title_full_unstemmed Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title_short Global Irradiation in Children Treated for Hydrocephalus and Its Change over Time—A Single Institutional Analysis
title_sort global irradiation in children treated for hydrocephalus and its change over time—a single institutional analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322797/
https://www.ncbi.nlm.nih.gov/pubmed/35884046
http://dx.doi.org/10.3390/children9071062
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