Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome

INTRODUCTION: Retromer complex proteins are decreased in Down syndrome (DS) brains and correlate inversely with brain amyloidosis. However, whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of DS remains unknown. METHODS: Human trisomic induced Pluripotent Stem...

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Detalles Bibliográficos
Autores principales: Curtis, Mary Elizabeth, Smith, Tiffany, Blass, Benjamin E., Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322819/
https://www.ncbi.nlm.nih.gov/pubmed/35910668
http://dx.doi.org/10.1002/trc2.12334

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