Cargando…

Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults

It is unclear whether physical activity and cardiorespiratory fitness (CRF) are pathways that link low pulmonary function (LPF) to increased blood pressure (BP). Therefore, we investigated the extent to which CRF and moderate-to-vigorous physical activity (MVPA) mediate the relationship between LPF...

Descripción completa

Detalles Bibliográficos
Autores principales: Almeida, F.R., Ostolin, T.L.V.D.P., Almeida, V.R., Gonze, B.B., Sperandio, E.F., Simões, M.S.M.P., Godoy, I., Tanni, S.E., Romiti, M., Arantes, R.L., Dourado, V.Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322832/
https://www.ncbi.nlm.nih.gov/pubmed/35894380
http://dx.doi.org/10.1590/1414-431X2022e11754
_version_ 1784756401454710784
author Almeida, F.R.
Ostolin, T.L.V.D.P.
Almeida, V.R.
Gonze, B.B.
Sperandio, E.F.
Simões, M.S.M.P.
Godoy, I.
Tanni, S.E.
Romiti, M.
Arantes, R.L.
Dourado, V.Z.
author_facet Almeida, F.R.
Ostolin, T.L.V.D.P.
Almeida, V.R.
Gonze, B.B.
Sperandio, E.F.
Simões, M.S.M.P.
Godoy, I.
Tanni, S.E.
Romiti, M.
Arantes, R.L.
Dourado, V.Z.
author_sort Almeida, F.R.
collection PubMed
description It is unclear whether physical activity and cardiorespiratory fitness (CRF) are pathways that link low pulmonary function (LPF) to increased blood pressure (BP). Therefore, we investigated the extent to which CRF and moderate-to-vigorous physical activity (MVPA) mediate the relationship between LPF and high BP in adults. We conducted a cross-sectional study with 1,362 participants that underwent cardiopulmonary exercise testing (CPET), spirometry, and wore an accelerometer to determine physical activity patterns. We performed mediation analyses using structural equations considering peak oxygen uptake (V̇O(2)) and MVPA as mediators, forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) as independent variables, and systolic and diastolic blood pressure (SBP, DBP) as dependent variables. The probability of alpha error was set at 5%. We found a significant total effect of FVC on SBP and DBP considering V̇O(2) as mediator (P<0.01). Indirect effects were also significant, with 42.6% of the total effect of FVC on SBP and 77% on DBP mediated by V̇O(2) (P<0.01). We did not observe a direct effect of FVC on SBP and DBP. Considering FEV1 as an independent variable, the total effect on SBP was also significant, as were the indirect effects, mediated by V̇O(2) at 14.8% for SBP and 7.6% for DBP (P<0.01). We did not find an indirect effect of FVC or FEV1 considering the MVPA as a mediator. CRF mediates the pathway that links LPF and elevated BP. Therefore, CRF is more sensitive to variations in FVC and FEV1 than MVPA.
format Online
Article
Text
id pubmed-9322832
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Associação Brasileira de Divulgação Científica
record_format MEDLINE/PubMed
spelling pubmed-93228322022-08-09 Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults Almeida, F.R. Ostolin, T.L.V.D.P. Almeida, V.R. Gonze, B.B. Sperandio, E.F. Simões, M.S.M.P. Godoy, I. Tanni, S.E. Romiti, M. Arantes, R.L. Dourado, V.Z. Braz J Med Biol Res Research Article It is unclear whether physical activity and cardiorespiratory fitness (CRF) are pathways that link low pulmonary function (LPF) to increased blood pressure (BP). Therefore, we investigated the extent to which CRF and moderate-to-vigorous physical activity (MVPA) mediate the relationship between LPF and high BP in adults. We conducted a cross-sectional study with 1,362 participants that underwent cardiopulmonary exercise testing (CPET), spirometry, and wore an accelerometer to determine physical activity patterns. We performed mediation analyses using structural equations considering peak oxygen uptake (V̇O(2)) and MVPA as mediators, forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) as independent variables, and systolic and diastolic blood pressure (SBP, DBP) as dependent variables. The probability of alpha error was set at 5%. We found a significant total effect of FVC on SBP and DBP considering V̇O(2) as mediator (P<0.01). Indirect effects were also significant, with 42.6% of the total effect of FVC on SBP and 77% on DBP mediated by V̇O(2) (P<0.01). We did not observe a direct effect of FVC on SBP and DBP. Considering FEV1 as an independent variable, the total effect on SBP was also significant, as were the indirect effects, mediated by V̇O(2) at 14.8% for SBP and 7.6% for DBP (P<0.01). We did not find an indirect effect of FVC or FEV1 considering the MVPA as a mediator. CRF mediates the pathway that links LPF and elevated BP. Therefore, CRF is more sensitive to variations in FVC and FEV1 than MVPA. Associação Brasileira de Divulgação Científica 2022-07-25 /pmc/articles/PMC9322832/ /pubmed/35894380 http://dx.doi.org/10.1590/1414-431X2022e11754 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Almeida, F.R.
Ostolin, T.L.V.D.P.
Almeida, V.R.
Gonze, B.B.
Sperandio, E.F.
Simões, M.S.M.P.
Godoy, I.
Tanni, S.E.
Romiti, M.
Arantes, R.L.
Dourado, V.Z.
Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title_full Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title_fullStr Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title_full_unstemmed Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title_short Cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
title_sort cardiorespiratory fitness as a mediator in the relationship between lung function and blood pressure in adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322832/
https://www.ncbi.nlm.nih.gov/pubmed/35894380
http://dx.doi.org/10.1590/1414-431X2022e11754
work_keys_str_mv AT almeidafr cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT ostolintlvdp cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT almeidavr cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT gonzebb cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT sperandioef cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT simoesmsmp cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT godoyi cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT tannise cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT romitim cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT arantesrl cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults
AT douradovz cardiorespiratoryfitnessasamediatorintherelationshipbetweenlungfunctionandbloodpressureinadults