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Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value

Objective and design: Following COVID-19 infection, children can develop an hyperinflammatory state termed Multisystem Inflammatory Syndrome in Children (MIS-C). Lung Ultrasound (LUS) features of COVID-19 in children have been described, but data describing the LUS findings of MIS-C are limited. The...

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Autores principales: Camporesi, Anna, Gemma, Marco, Buonsenso, Danilo, Ferrario, Stefania, Mandelli, Anna, Pessina, Matteo, Diotto, Veronica, Rota, Elena, Raso, Irene, Fiori, Laura, Campari, Alessandro, Izzo, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322869/
https://www.ncbi.nlm.nih.gov/pubmed/35883915
http://dx.doi.org/10.3390/children9070931
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author Camporesi, Anna
Gemma, Marco
Buonsenso, Danilo
Ferrario, Stefania
Mandelli, Anna
Pessina, Matteo
Diotto, Veronica
Rota, Elena
Raso, Irene
Fiori, Laura
Campari, Alessandro
Izzo, Francesca
author_facet Camporesi, Anna
Gemma, Marco
Buonsenso, Danilo
Ferrario, Stefania
Mandelli, Anna
Pessina, Matteo
Diotto, Veronica
Rota, Elena
Raso, Irene
Fiori, Laura
Campari, Alessandro
Izzo, Francesca
author_sort Camporesi, Anna
collection PubMed
description Objective and design: Following COVID-19 infection, children can develop an hyperinflammatory state termed Multisystem Inflammatory Syndrome in Children (MIS-C). Lung Ultrasound (LUS) features of COVID-19 in children have been described, but data describing the LUS findings of MIS-C are limited. The aim of this retrospective observational study conducted between 1 March and 31 December 2020, at a tertiary pediatric hospital in Milano, is to describe LUS patterns in patients with MIS-C and to verify correlation with illness severity. The secondary objective is to evaluate concordance of LUS with Chest X-ray (CXR). Methodology: Clinical and laboratory data were collected for all patients (age 0–18 years) admitted with MIS-C, as well as LUS and CXR patterns at admission. PICU admission, needed for respiratory support and inotrope administration, hospital, and PICU length of stay, were considered as outcomes and evaluated in the different LUS patterns. An agreement between LUS and CXR evaluation was assessed with Cohen’ k. Results: 24 children, who had a LUS examination upon admission, were enrolled. LUS pattern of subpleural consolidations < or > 1 cm with or without pleural effusion were associated with worse Left Ventricular Ejection Fraction at admission and need for inotropes. Subpleural consolidations < 1 cm were also associated with PICU length of stay. Agreement of CXR with LUS for consolidations and effusion was slight. Conclusion: LUS pattern of subpleural consolidations and consolidations with or without pleural effusion are predictors of disease severity; under this aspect, LUS can be used at admission to stratify risk of severe disease.
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spelling pubmed-93228692022-07-27 Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value Camporesi, Anna Gemma, Marco Buonsenso, Danilo Ferrario, Stefania Mandelli, Anna Pessina, Matteo Diotto, Veronica Rota, Elena Raso, Irene Fiori, Laura Campari, Alessandro Izzo, Francesca Children (Basel) Article Objective and design: Following COVID-19 infection, children can develop an hyperinflammatory state termed Multisystem Inflammatory Syndrome in Children (MIS-C). Lung Ultrasound (LUS) features of COVID-19 in children have been described, but data describing the LUS findings of MIS-C are limited. The aim of this retrospective observational study conducted between 1 March and 31 December 2020, at a tertiary pediatric hospital in Milano, is to describe LUS patterns in patients with MIS-C and to verify correlation with illness severity. The secondary objective is to evaluate concordance of LUS with Chest X-ray (CXR). Methodology: Clinical and laboratory data were collected for all patients (age 0–18 years) admitted with MIS-C, as well as LUS and CXR patterns at admission. PICU admission, needed for respiratory support and inotrope administration, hospital, and PICU length of stay, were considered as outcomes and evaluated in the different LUS patterns. An agreement between LUS and CXR evaluation was assessed with Cohen’ k. Results: 24 children, who had a LUS examination upon admission, were enrolled. LUS pattern of subpleural consolidations < or > 1 cm with or without pleural effusion were associated with worse Left Ventricular Ejection Fraction at admission and need for inotropes. Subpleural consolidations < 1 cm were also associated with PICU length of stay. Agreement of CXR with LUS for consolidations and effusion was slight. Conclusion: LUS pattern of subpleural consolidations and consolidations with or without pleural effusion are predictors of disease severity; under this aspect, LUS can be used at admission to stratify risk of severe disease. MDPI 2022-06-21 /pmc/articles/PMC9322869/ /pubmed/35883915 http://dx.doi.org/10.3390/children9070931 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Camporesi, Anna
Gemma, Marco
Buonsenso, Danilo
Ferrario, Stefania
Mandelli, Anna
Pessina, Matteo
Diotto, Veronica
Rota, Elena
Raso, Irene
Fiori, Laura
Campari, Alessandro
Izzo, Francesca
Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title_full Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title_fullStr Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title_full_unstemmed Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title_short Lung Ultrasound Patterns in Multisystem Inflammatory Syndrome in Children (MIS-C)-Characteristics and Prognostic Value
title_sort lung ultrasound patterns in multisystem inflammatory syndrome in children (mis-c)-characteristics and prognostic value
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322869/
https://www.ncbi.nlm.nih.gov/pubmed/35883915
http://dx.doi.org/10.3390/children9070931
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