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Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)

Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not completely elucidated. The current review aims to summarize the mos...

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Autores principales: Mioc, Marius, Milan, Andreea, Malița, Daniel, Mioc, Alexandra, Prodea, Alexandra, Racoviceanu, Roxana, Ghiulai, Roxana, Cristea, Andreea, Căruntu, Florina, Șoica, Codruța
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322890/
https://www.ncbi.nlm.nih.gov/pubmed/35887090
http://dx.doi.org/10.3390/ijms23147740
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author Mioc, Marius
Milan, Andreea
Malița, Daniel
Mioc, Alexandra
Prodea, Alexandra
Racoviceanu, Roxana
Ghiulai, Roxana
Cristea, Andreea
Căruntu, Florina
Șoica, Codruța
author_facet Mioc, Marius
Milan, Andreea
Malița, Daniel
Mioc, Alexandra
Prodea, Alexandra
Racoviceanu, Roxana
Ghiulai, Roxana
Cristea, Andreea
Căruntu, Florina
Șoica, Codruța
author_sort Mioc, Marius
collection PubMed
description Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not completely elucidated. The current review aims to summarize the most recent literature, published in the last five years, regarding the mechanism of action of three triterpenic acids (asiatic acid, oleanolic acid, and ursolic acid), corelated with different biological activities such as anticancer, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, and antimicrobial. All three discussed compounds share several mechanisms of action, such as the targeted modulation of the PI3K/AKT, Nrf2, NF-kB, EMT, and JAK/STAT3 signaling pathways, while other mechanisms that proved to only be specific for a part of the triterpenic acids discussed, such as the modulation of Notch, Hippo, and MALAT1/miR-206/PTGS1 signaling pathway, were highlighted as well. This paper stands as the first part in our literature study on the topic, which will be followed by a second part focusing on other triterpenic acids of therapeutic value.
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spelling pubmed-93228902022-07-27 Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I) Mioc, Marius Milan, Andreea Malița, Daniel Mioc, Alexandra Prodea, Alexandra Racoviceanu, Roxana Ghiulai, Roxana Cristea, Andreea Căruntu, Florina Șoica, Codruța Int J Mol Sci Review Triterpenic acids are phytocompounds with a widespread range of biological activities that have been the subject of numerous in vitro and in vivo studies. However, their underlying mechanisms of action in various pathologies are not completely elucidated. The current review aims to summarize the most recent literature, published in the last five years, regarding the mechanism of action of three triterpenic acids (asiatic acid, oleanolic acid, and ursolic acid), corelated with different biological activities such as anticancer, anti-inflammatory, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, and antimicrobial. All three discussed compounds share several mechanisms of action, such as the targeted modulation of the PI3K/AKT, Nrf2, NF-kB, EMT, and JAK/STAT3 signaling pathways, while other mechanisms that proved to only be specific for a part of the triterpenic acids discussed, such as the modulation of Notch, Hippo, and MALAT1/miR-206/PTGS1 signaling pathway, were highlighted as well. This paper stands as the first part in our literature study on the topic, which will be followed by a second part focusing on other triterpenic acids of therapeutic value. MDPI 2022-07-13 /pmc/articles/PMC9322890/ /pubmed/35887090 http://dx.doi.org/10.3390/ijms23147740 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mioc, Marius
Milan, Andreea
Malița, Daniel
Mioc, Alexandra
Prodea, Alexandra
Racoviceanu, Roxana
Ghiulai, Roxana
Cristea, Andreea
Căruntu, Florina
Șoica, Codruța
Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title_full Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title_fullStr Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title_full_unstemmed Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title_short Recent Advances Regarding the Molecular Mechanisms of Triterpenic Acids: A Review (Part I)
title_sort recent advances regarding the molecular mechanisms of triterpenic acids: a review (part i)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322890/
https://www.ncbi.nlm.nih.gov/pubmed/35887090
http://dx.doi.org/10.3390/ijms23147740
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