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Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic
Celiac disease (CD) comprises over 1% of the world’s population and is a chronic multisystem immune-mediated condition manifested by digestive and/or extradigestive symptoms caused by food intake of gluten. This review looked at the risk of children diagnosed with CD developing SARS-CoV-2 infection...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322892/ https://www.ncbi.nlm.nih.gov/pubmed/35887067 http://dx.doi.org/10.3390/ijms23147719 |
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author | Ailioaie, Laura Marinela Ailioaie, Constantin Litscher, Gerhard Chiran, Dragos Andrei |
author_facet | Ailioaie, Laura Marinela Ailioaie, Constantin Litscher, Gerhard Chiran, Dragos Andrei |
author_sort | Ailioaie, Laura Marinela |
collection | PubMed |
description | Celiac disease (CD) comprises over 1% of the world’s population and is a chronic multisystem immune-mediated condition manifested by digestive and/or extradigestive symptoms caused by food intake of gluten. This review looked at the risk of children diagnosed with CD developing SARS-CoV-2 infection and possible severe forms of COVID-19. A better understanding of the interaction and effects of SARS-CoV-2 infection in CD is very important, as is the role of environmental and genetic factors, but especially the molecular mechanisms involved in modulating intestinal permeability with impact on autoimmunity. CD inspired the testing of a zonulin antagonist for the fulminant form of multisystem inflammatory syndrome in children (MIS-C) and paved the way for the discovery of new molecules to regulate the small intestine barrier function and immune responses. Original published works on COVID-19 and CD, new data and points of view have been analyzed because this dangerous virus SARS-CoV-2 is still here and yet influencing our lives. Medical science continues to focus on all uncertainties triggered by SARS-CoV-2 infection and its consequences, including in CD. Although the COVID-19 pandemic seems to be gradually extinguishing, there is a wealth of information and knowledge gained over the last two years and important life lessons to analyze, as well as relevant conclusions to be drawn to deal with future pandemics. Zonulin is being studied extensively in immunoengineering as an adjuvant to improving the absorption of new drugs and oral vaccines. |
format | Online Article Text |
id | pubmed-9322892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93228922022-07-27 Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic Ailioaie, Laura Marinela Ailioaie, Constantin Litscher, Gerhard Chiran, Dragos Andrei Int J Mol Sci Review Celiac disease (CD) comprises over 1% of the world’s population and is a chronic multisystem immune-mediated condition manifested by digestive and/or extradigestive symptoms caused by food intake of gluten. This review looked at the risk of children diagnosed with CD developing SARS-CoV-2 infection and possible severe forms of COVID-19. A better understanding of the interaction and effects of SARS-CoV-2 infection in CD is very important, as is the role of environmental and genetic factors, but especially the molecular mechanisms involved in modulating intestinal permeability with impact on autoimmunity. CD inspired the testing of a zonulin antagonist for the fulminant form of multisystem inflammatory syndrome in children (MIS-C) and paved the way for the discovery of new molecules to regulate the small intestine barrier function and immune responses. Original published works on COVID-19 and CD, new data and points of view have been analyzed because this dangerous virus SARS-CoV-2 is still here and yet influencing our lives. Medical science continues to focus on all uncertainties triggered by SARS-CoV-2 infection and its consequences, including in CD. Although the COVID-19 pandemic seems to be gradually extinguishing, there is a wealth of information and knowledge gained over the last two years and important life lessons to analyze, as well as relevant conclusions to be drawn to deal with future pandemics. Zonulin is being studied extensively in immunoengineering as an adjuvant to improving the absorption of new drugs and oral vaccines. MDPI 2022-07-13 /pmc/articles/PMC9322892/ /pubmed/35887067 http://dx.doi.org/10.3390/ijms23147719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ailioaie, Laura Marinela Ailioaie, Constantin Litscher, Gerhard Chiran, Dragos Andrei Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title | Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title_full | Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title_fullStr | Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title_full_unstemmed | Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title_short | Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic |
title_sort | celiac disease and targeting the molecular mechanisms of autoimmunity in covid pandemic |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322892/ https://www.ncbi.nlm.nih.gov/pubmed/35887067 http://dx.doi.org/10.3390/ijms23147719 |
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