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MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (...

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Autores principales: Wani, Javaid Ahmad, Majid, Sabhiya, Imtiyaz, Zuha, Rehman, Muneeb U., Alsaffar, Rana M., Shah, Naveed Nazir, Alshehri, Sultan, Ghoneim, Mohammed M., Imam, Syed Sarim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322918/
https://www.ncbi.nlm.nih.gov/pubmed/35885514
http://dx.doi.org/10.3390/diagnostics12071610
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author Wani, Javaid Ahmad
Majid, Sabhiya
Imtiyaz, Zuha
Rehman, Muneeb U.
Alsaffar, Rana M.
Shah, Naveed Nazir
Alshehri, Sultan
Ghoneim, Mohammed M.
Imam, Syed Sarim
author_facet Wani, Javaid Ahmad
Majid, Sabhiya
Imtiyaz, Zuha
Rehman, Muneeb U.
Alsaffar, Rana M.
Shah, Naveed Nazir
Alshehri, Sultan
Ghoneim, Mohammed M.
Imam, Syed Sarim
author_sort Wani, Javaid Ahmad
collection PubMed
description Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.
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spelling pubmed-93229182022-07-27 MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential Wani, Javaid Ahmad Majid, Sabhiya Imtiyaz, Zuha Rehman, Muneeb U. Alsaffar, Rana M. Shah, Naveed Nazir Alshehri, Sultan Ghoneim, Mohammed M. Imam, Syed Sarim Diagnostics (Basel) Review Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer. MDPI 2022-07-01 /pmc/articles/PMC9322918/ /pubmed/35885514 http://dx.doi.org/10.3390/diagnostics12071610 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wani, Javaid Ahmad
Majid, Sabhiya
Imtiyaz, Zuha
Rehman, Muneeb U.
Alsaffar, Rana M.
Shah, Naveed Nazir
Alshehri, Sultan
Ghoneim, Mohammed M.
Imam, Syed Sarim
MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title_full MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title_fullStr MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title_full_unstemmed MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title_short MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
title_sort mirnas in lung cancer: diagnostic, prognostic, and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322918/
https://www.ncbi.nlm.nih.gov/pubmed/35885514
http://dx.doi.org/10.3390/diagnostics12071610
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