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MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential
Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322918/ https://www.ncbi.nlm.nih.gov/pubmed/35885514 http://dx.doi.org/10.3390/diagnostics12071610 |
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author | Wani, Javaid Ahmad Majid, Sabhiya Imtiyaz, Zuha Rehman, Muneeb U. Alsaffar, Rana M. Shah, Naveed Nazir Alshehri, Sultan Ghoneim, Mohammed M. Imam, Syed Sarim |
author_facet | Wani, Javaid Ahmad Majid, Sabhiya Imtiyaz, Zuha Rehman, Muneeb U. Alsaffar, Rana M. Shah, Naveed Nazir Alshehri, Sultan Ghoneim, Mohammed M. Imam, Syed Sarim |
author_sort | Wani, Javaid Ahmad |
collection | PubMed |
description | Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer. |
format | Online Article Text |
id | pubmed-9322918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93229182022-07-27 MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential Wani, Javaid Ahmad Majid, Sabhiya Imtiyaz, Zuha Rehman, Muneeb U. Alsaffar, Rana M. Shah, Naveed Nazir Alshehri, Sultan Ghoneim, Mohammed M. Imam, Syed Sarim Diagnostics (Basel) Review Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer. MDPI 2022-07-01 /pmc/articles/PMC9322918/ /pubmed/35885514 http://dx.doi.org/10.3390/diagnostics12071610 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wani, Javaid Ahmad Majid, Sabhiya Imtiyaz, Zuha Rehman, Muneeb U. Alsaffar, Rana M. Shah, Naveed Nazir Alshehri, Sultan Ghoneim, Mohammed M. Imam, Syed Sarim MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title | MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title_full | MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title_fullStr | MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title_full_unstemmed | MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title_short | MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential |
title_sort | mirnas in lung cancer: diagnostic, prognostic, and therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322918/ https://www.ncbi.nlm.nih.gov/pubmed/35885514 http://dx.doi.org/10.3390/diagnostics12071610 |
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