In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme

The microsomal cytochrome P450 3A4 (CYP3A4) and mitochondrial cytochrome P450 24A1 (CYP24A1) hydroxylating enzymes both metabolize vitamin D and its analogs. The three-dimensional (3D) structure of the full-length native human CYP3A4 has been solved, but the respective structure of the main vitamin...

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Detalles Bibliográficos
Autores principales: Żołek, Teresa, Yasuda, Kaori, Brown, Geoffrey, Sakaki, Toshiyuki, Kutner, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322940/
https://www.ncbi.nlm.nih.gov/pubmed/35887195
http://dx.doi.org/10.3390/ijms23147845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322940/
https://www.ncbi.nlm.nih.gov/pubmed/35887195
http://dx.doi.org/10.3390/ijms23147845

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