Cargando…

In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme

The microsomal cytochrome P450 3A4 (CYP3A4) and mitochondrial cytochrome P450 24A1 (CYP24A1) hydroxylating enzymes both metabolize vitamin D and its analogs. The three-dimensional (3D) structure of the full-length native human CYP3A4 has been solved, but the respective structure of the main vitamin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Żołek, Teresa, Yasuda, Kaori, Brown, Geoffrey, Sakaki, Toshiyuki, Kutner, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322940/ https://www.ncbi.nlm.nih.gov/pubmed/35887195 http://dx.doi.org/10.3390/ijms23147845

Ejemplares similares

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D(2) Derivatives Modified at the Side Chain and the A-Ring
por: Milczarek, Magdalena, et al.
Publicado: (2020)

Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D(3) Analogues
por: Kawagoe, Fumihiro, et al.
Publicado: (2019)

Nonaqueous Capillary Electrophoretic Separation of Analogs of (24R)-1,24-Dihydroxyvitamin D(3) Derivative as Predicted by Quantum Chemical Calculations
por: Grodner, Błażej, et al.
Publicado: (2023)

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D(2) as Potential Anti-Leukemic Agents
por: Corcoran, Aoife, et al.
Publicado: (2016)

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis
por: Yasuda, Kaori, et al.
Publicado: (2015)

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system
por: Yasuda, Kaori, et al.
Publicado: (2021)

Vitamins D: Relationship between Structure and Biological Activity
por: Kutner, Andrzej, et al.
Publicado: (2018)

Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells
por: Piatek, Karina, et al.
Publicado: (2021)

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D(3) Analogues and Their Stability to hCYP24A1-Dependent Catabolism
por: Kawagoe, Fumihiro, et al.
Publicado: (2021)

Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D(2) Against Human Malignant Melanoma Cell Lines
por: Piotrowska, Anna, et al.
Publicado: (2016)

Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model
por: Milczarek, Magdalena, et al.
Publicado: (2013)

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment
por: MILCZAREK, MAGDALENA, et al.
Publicado: (2014)

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery
por: Yasuda, Kaori, et al.
Publicado: (2021)

Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor
por: Iwai, Yuichiro, et al.
Publicado: (2023)

Polytyramine Film-Coated Single-Walled Carbon Nanotube Electrochemical Chemosensor with Molecularly Imprinted Polymer Nanoparticles for Duloxetine-Selective Determination in Human Plasma
por: Jyoti,, et al.
Publicado: (2022)

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats
por: Nishikawa, Miyu, et al.
Publicado: (2022)

Vitamin D Analogs Potentiate the Antitumor Effect of Imatinib Mesylate in a Human A549 Lung Tumor Model
por: Maj, Ewa, et al.
Publicado: (2015)

Metabolism of ropinirole is mediated by several canine CYP enzymes
por: Tervahauta, Tuomas, et al.
Publicado: (2023)

Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D
por: Berkowska, Klaudia, et al.
Publicado: (2019)

CYP450 Enzyme-Mediated Metabolism of TCAS and Its Inhibitory and Induced Effects on Metabolized Enzymes in Vitro
por: Shen, Guolin, et al.
Publicado: (2015)

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D(3) and Identification of Their Metabolites
por: Mizumoto, Yuka, et al.
Publicado: (2023)

Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis()
por: Ramasamy, Adaikalavan, et al.
Publicado: (2014)

In Silico Studies of Novel Vemurafenib Derivatives as BRAF Kinase Inhibitors
por: Żołek, Teresa, et al.
Publicado: (2023)

In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
por: Reid, Anna-Mari, et al.
Publicado: (2019)

Prodifferentiation Activity of Novel Vitamin D(2) Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells
por: Nachliely, Matan, et al.
Publicado: (2016)

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study
por: Xia, Yuting, et al.
Publicado: (2023)

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase
por: Yasuda, Kaori, et al.
Publicado: (2015)

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
por: Kise, Satoko, et al.
Publicado: (2023)

Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis
por: Wen, Jing, et al.
Publicado: (2021)

Association of CYP2R1 and CYP27B1 genes with the risk of obesity and vitamin D metabolism in Saudi women
por: AlSedairy, Sahar Abdulaziz, et al.
Publicado: (2023)

Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling
por: Juvonen, Risto O., et al.
Publicado: (2021)

Functional Analogy in Human Metabolism: Enzymes with Different Biological Roles or Functional Redundancy?
por: Piergiorge, Rafael Mina, et al.
Publicado: (2017)

The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D(3) and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities
por: Mototani, Sayuri, et al.
Publicado: (2022)

Polymorphisms of drug-metabolizing enzyme CYP2E1 in Chinese Uygur population
por: Zhu, Linhao, et al.
Publicado: (2018)

The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
por: Šarić Mustapić, Darija, et al.
Publicado: (2018)

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren
por: Kong, Ronald, et al.
Publicado: (2020)

CYP2A13 Acts as the Main Metabolic CYP450s Enzyme for Activating Leonurine in Human Bronchial Epithelial Cells
por: Xu, Ting, et al.
Publicado: (2020)

The future of vitamin D analogs
por: Leyssens, Carlien, et al.
Publicado: (2014)

Combination Analysis in Genetic Polymorphisms of Drug-Metabolizing Enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese Population
por: Ota, Tomoko, et al.
Publicado: (2015)

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism
por: Dias, Vera, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_0235g7em8rh5saopgmuhp2svk0