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Population Pharmacokinetics of Palbociclib and Its Correlation with Clinical Efficacy and Safety in Patients with Advanced Breast Cancer

Neutropenia is the most frequent dose-limiting toxicity reported in patients with metastatic breast cancer receiving palbociclib. The objective of this study was to investigate the pharmacokinetic–pharmacodynamic (PK/PD) relationships for toxicity (i.e., absolute neutrophil count, ANC) and efficacy...

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Detalles Bibliográficos
Autores principales:	Courlet, Perrine, Cardoso, Evelina, Bandiera, Carole, Stravodimou, Athina, Zurcher, Jean-Philippe, Chtioui, Haithem, Locatelli, Isabella, Decosterd, Laurent Arthur, Darnaud, Léa, Blanchet, Benoit, Alexandre, Jérôme, Wagner, Anna Dorothea, Zaman, Khalil, Schneider, Marie Paule, Guidi, Monia, Csajka, Chantal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322950/ https://www.ncbi.nlm.nih.gov/pubmed/35890213 http://dx.doi.org/10.3390/pharmaceutics14071317

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