Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

BACKGROUND: We recently developed a multi-ancestry polygenic risk score (PRS) that effectively stratifies prostate cancer risk across populations. In this study, we validated the performance of the PRS in the multi-ancestry Million Veteran Program and additional independent studies. METHODS: Within...

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Detalles Bibliográficos
Autores principales: Chen, Fei, Darst, Burcu F, Madduri, Ravi K, Rodriguez, Alex A, Sheng, Xin, Rentsch, Christopher T, Andrews, Caroline, Tang, Wei, Kibel, Adam S, Plym, Anna, Cho, Kelly, Jalloh, Mohamed, Gueye, Serigne Magueye, Niang, Lamine, Ogunbiyi, Olufemi J, Popoola, Olufemi, Adebiyi, Akindele O, Aisuodionoe-Shadrach, Oseremen I, Ajibola, Hafees O, Jamda, Mustapha A, Oluwole, Olabode P, Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Mensah, James E, Adjei, Andrew Anthony, Diop, Halimatou, Lachance, Joseph, Rebbeck, Timothy R, Ambs, Stefan, Gaziano, J Michael, Justice, Amy C, Conti, David V, Haiman, Christopher A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322982/
https://www.ncbi.nlm.nih.gov/pubmed/35801699
http://dx.doi.org/10.7554/eLife.78304

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