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Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics
Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantif...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323001/ https://www.ncbi.nlm.nih.gov/pubmed/35880398 http://dx.doi.org/10.7554/eLife.76605 |
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author | Cancino-Muñoz, Irving López, Mariana G Torres-Puente, Manuela Villamayor, Luis M Borrás, Rafael Borrás-Máñez, María Bosque, Montserrat Camarena, Juan J Colijn, Caroline Colomer-Roig, Ester Colomina, Javier Escribano, Isabel Esparcia-Rodríguez, Oscar García-García, Francisco Gil-Brusola, Ana Gimeno, Concepción Gimeno-Gascón, Adelina Gomila-Sard, Bárbara Gónzales-Granda, Damiana Gonzalo-Jiménez, Nieves Guna-Serrano, María Remedios López-Hontangas, José Luis Martín-González, Coral Moreno-Muñoz, Rosario Navarro, David Navarro, María Orta, Nieves Pérez, Elvira Prat, Josep Rodríguez, Juan Carlos Ruiz-García, Ma Montserrat Vanaclocha, Hermelinda Comas, Iñaki |
author_facet | Cancino-Muñoz, Irving López, Mariana G Torres-Puente, Manuela Villamayor, Luis M Borrás, Rafael Borrás-Máñez, María Bosque, Montserrat Camarena, Juan J Colijn, Caroline Colomer-Roig, Ester Colomina, Javier Escribano, Isabel Esparcia-Rodríguez, Oscar García-García, Francisco Gil-Brusola, Ana Gimeno, Concepción Gimeno-Gascón, Adelina Gomila-Sard, Bárbara Gónzales-Granda, Damiana Gonzalo-Jiménez, Nieves Guna-Serrano, María Remedios López-Hontangas, José Luis Martín-González, Coral Moreno-Muñoz, Rosario Navarro, David Navarro, María Orta, Nieves Pérez, Elvira Prat, Josep Rodríguez, Juan Carlos Ruiz-García, Ma Montserrat Vanaclocha, Hermelinda Comas, Iñaki |
author_sort | Cancino-Muñoz, Irving |
collection | PubMed |
description | Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application. Here, we generate a population-based dataset from Valencia region and compare it with available datasets from different TB-burden settings to reveal transmission dynamics heterogeneity and its public health implications. We sequenced the whole genome of 785 Mycobacterium tuberculosis strains and linked genomes to patient epidemiological data. We use a pairwise distance clustering approach and phylodynamic methods to characterize transmission events over the last 150 years, in different TB-burden regions. Our results underscore significant differences in transmission between low-burden TB settings, i.e., clustering in Valencia region is higher (47.4%) than in Oxfordshire (27%), and similar to a high-burden area as Malawi (49.8%). By modeling times of the transmission links, we observed that settings with high transmission rate are associated with decades of uninterrupted transmission, irrespective of burden. Together, our results reveal that burden and transmission are not necessarily linked due to the role of past epidemics in the ongoing TB incidence, and highlight the need for in-depth characterization of transmission dynamics and specifically tailored TB control strategies. |
format | Online Article Text |
id | pubmed-9323001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-93230012022-07-27 Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics Cancino-Muñoz, Irving López, Mariana G Torres-Puente, Manuela Villamayor, Luis M Borrás, Rafael Borrás-Máñez, María Bosque, Montserrat Camarena, Juan J Colijn, Caroline Colomer-Roig, Ester Colomina, Javier Escribano, Isabel Esparcia-Rodríguez, Oscar García-García, Francisco Gil-Brusola, Ana Gimeno, Concepción Gimeno-Gascón, Adelina Gomila-Sard, Bárbara Gónzales-Granda, Damiana Gonzalo-Jiménez, Nieves Guna-Serrano, María Remedios López-Hontangas, José Luis Martín-González, Coral Moreno-Muñoz, Rosario Navarro, David Navarro, María Orta, Nieves Pérez, Elvira Prat, Josep Rodríguez, Juan Carlos Ruiz-García, Ma Montserrat Vanaclocha, Hermelinda Comas, Iñaki eLife Epidemiology and Global Health Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with assumed negligible impact in low-burden areas. However, we still lack a full characterization of transmission dynamics in settings with similar and different burdens. Genomic epidemiology can greatly help to quantify transmission, but the lack of whole genome sequencing population-based studies has hampered its application. Here, we generate a population-based dataset from Valencia region and compare it with available datasets from different TB-burden settings to reveal transmission dynamics heterogeneity and its public health implications. We sequenced the whole genome of 785 Mycobacterium tuberculosis strains and linked genomes to patient epidemiological data. We use a pairwise distance clustering approach and phylodynamic methods to characterize transmission events over the last 150 years, in different TB-burden regions. Our results underscore significant differences in transmission between low-burden TB settings, i.e., clustering in Valencia region is higher (47.4%) than in Oxfordshire (27%), and similar to a high-burden area as Malawi (49.8%). By modeling times of the transmission links, we observed that settings with high transmission rate are associated with decades of uninterrupted transmission, irrespective of burden. Together, our results reveal that burden and transmission are not necessarily linked due to the role of past epidemics in the ongoing TB incidence, and highlight the need for in-depth characterization of transmission dynamics and specifically tailored TB control strategies. eLife Sciences Publications, Ltd 2022-07-26 /pmc/articles/PMC9323001/ /pubmed/35880398 http://dx.doi.org/10.7554/eLife.76605 Text en © 2022, Cancino-Muñoz, López et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Epidemiology and Global Health Cancino-Muñoz, Irving López, Mariana G Torres-Puente, Manuela Villamayor, Luis M Borrás, Rafael Borrás-Máñez, María Bosque, Montserrat Camarena, Juan J Colijn, Caroline Colomer-Roig, Ester Colomina, Javier Escribano, Isabel Esparcia-Rodríguez, Oscar García-García, Francisco Gil-Brusola, Ana Gimeno, Concepción Gimeno-Gascón, Adelina Gomila-Sard, Bárbara Gónzales-Granda, Damiana Gonzalo-Jiménez, Nieves Guna-Serrano, María Remedios López-Hontangas, José Luis Martín-González, Coral Moreno-Muñoz, Rosario Navarro, David Navarro, María Orta, Nieves Pérez, Elvira Prat, Josep Rodríguez, Juan Carlos Ruiz-García, Ma Montserrat Vanaclocha, Hermelinda Comas, Iñaki Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title | Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title_full | Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title_fullStr | Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title_full_unstemmed | Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title_short | Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
title_sort | population-based sequencing of mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics |
topic | Epidemiology and Global Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323001/ https://www.ncbi.nlm.nih.gov/pubmed/35880398 http://dx.doi.org/10.7554/eLife.76605 |
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